In 1839-1840, the ichthyologist Richard Parnell left London for a collecting expedition to Jamaica and a tour of museum collections in the United States. An authority on both fishes and grasses, Parnell published two noted works as a young man, his Prize Essay on the Natural and Economical History of the Fishes Marine, Fluviatile, and Lacustrine, of the River District of the Firth of Forth (Edinburgh: Neill and Co., 1838) and The Grasses of Britain, 2 vols. (Edinburgh: Blackwood, 1842-1845). He appears, however, to have abandoned publication in 1845, although he continued collecting for many years. The notebook kept by Richard Parnell during his voyage to the West Indies and United States in 1839-1840 contains little narrative, but dozens of pencil and watercolor sketches of the marine life that absorbed his interest, primarily fishes. Most sketches are accompanied by brief notes on the anatomy of the fish, sometimes with close-ups of fin structures, air bladders, or the digestive tract and stomach. Although collecting localities are seldom recorded, the majority of specimens seem to have been collected in Jamaica, with at least a few observed in vitro at the New York Museum.

The Sketches of a Tour of the Lakes, of the character & customs of the Chippeway Indians & of incidents connected with the treaty of Fond du Lac... to which is super added a vocabulary of the Algic, or Chippeway language... is a record of a journey undertaken by Thomas L. McKenney and Lewis Cass, from Washington, D.C., to Fond du Lac, Wisc., to negotiate a treaty with the Chippewa and other Indians. McKenney, the Superindenant of Indian Affairs, includes an account of travel on the Great Lakes, and more memorably, a description of the "character" and customs of the Chippewa Indians, an account of the treaty of Fond du Lac, and a vocabulary of the Algic or Chippewa language. The manuscript, a fair copy of the original sent to a London publisher, is illustrated throughout with watercolor sketches of scenes and persons. It was originally published in Baltimore in 1827.

A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.