The Reina Papers contain the professional papers of cultural anthropologist Ruben E. Reina (1924-2016). Reina is an emeritus professor of anthropology and curator of ethnology who taught at the University of Pennsylvania and worked at that institution's University Museum of Archeology and Anthropology from 1957-1990. Broadly interested in modern and historical cultures of Central America, South America, and Spain, he is most widely known for his contributions to the study of the culture and peoples of Guatemala. The collection contains Reina's correspondence, administrative records, teaching materials, research notes, subject files, and written works from his career. Of particular interest are the notes from his fieldwork in Guatemala, Argentina, Spain, and Puerto Rico. A further significant component of the papers is the records of the Hispanic-Latin American Research Project. Reina served as director of the long-term project (1967-1988), during which a team of scholars compiled thousands of pages of Spanish colonial materials from the Archivo General de Indias (AGI) in Seville, Spain and Archivos General de Centro America (AGCA) in Guatemala. The Reina Papers serve as a vital storehouse of this important historical material.

An anthropologist and student of Native American cultures, Elisabeth Tooker devoted a long career, much of it as a professor at Temple University, to study of the culture and ethnohistory of the Haudenosaunee of New York State. The Tooker Papers is arranged in six series, and contain her correspondence, subject files, research notes, and both published and unpublished papers.

An anthropologist, Pamela Wallace was the Head of Education at the Sam Noble Oklahoma Museum of Natural History at the University of Oklahoma. The papers include correspondence, research, works by Wallace, audio recordings, color slides, photographs, and videos of Yuchi Indians.

Though the Miscellaneous Manuscripts collection is composed of items that do not fall readily into any other existing collection, the two dominant intellectual areas represented in the collection are Early American History and History of Science.

The Anthony F. C. Wallace Papers include correspondence to and from 20th century anthropologists, ethnologists, historians, linguists, and psychiatrists and provides a wealth of resources for the study of technological and social change, American Indians, culture and personality, revitalization movements, the anthropological study of religion, and the cultural and biological bases of behavior. In addition to Wallace's correspondence, research notes, and drafts, the collection includes Wallace family correspondence and photographs, as well as Wallace's writings from childhood through recent years.