The approximately 3,700 color and black and white drawings were collected and drawn by John Lawrence LeConte, with two in the first volume are by Titian R. Peale, but most are likely by John Abbot. The previous description noted that there are some drawings by John Abbot, and that most were likely by John Lawrence Le Conte. However, John V. Calhoun has shown extensive evidence that most of the drawings are by John Abbot (John Abbot's "Lost" Drawings for John E. LeConte in the American Philosophical Society Library, Philadelphia. Journal of the Lepidopterists' Society 60(4), 2006, 211-217). The contents of the collection: 1. Coleoptera. 654 figures. 2. Diptera, Hemiptera, and Lepidoptera. 564 figures. 3. Coleoptera. 698 figures. 4. Coleoptera and Hymenoptera. 228 figures. 5. Coleoptera. 657 figures. 6. Hymenoptera and Diptera. 234 figures 7. Diptera. 304 figures. 8. Hemiptera, Araneina, Myripoda. 356 figures

This volume contains medical notes by Wistar, including observations on yellow fever and arguments to prove its foreign origin, facts relative to the progress of the fever in 1797, the infection and death of Colonel Van Emburgh, the infection of the crew of the ship "Deborah" and of the Durham boat (1802), an account of the diseases which afflicted the family of James Hammar in Montgomery County (Pa.), facts relating to the typhus fever of 1812-1813, case histories (1796-1803), temperature chart (1758-1759, 1760), and a thermometrical journal (1760-1765) kept by Charles Norris and copied by Wistar from notes in possession of Joseph Parker Norris.

This set of journals, copied legibly but with many excisions into the last volume, 914 Sm61, is from a tour of Germany, Denmark, Sweden, France, and England, to inspect technological improvements in manufacturing and mining. There are accounts of visits with C.D. Ebeling, Friedrich Klopstock, J.A.J. Reimarus, Anders Sparmann, and Karl P. Thunberg. Smith bequeathed this journal to the American Philosophical Society with the request that it be published if found to contain information "useful to the manufactories of my country."

Between 1764 and 1781, the Scots surveyor George Gauld was assigned by the British Admirality to chart the waters of the Gulf Coast off British West Florida, an area that extended from New Orleans to the modern-day Florida. In 1773, Gauld submitted some of his findings to the APS, probably in hopes of having them published in the Transactions, and although these were not published, they became one of the first mansucripts entered into the Society's collections. Contains occasional brief references to Native peoples of the areas described. The Gauld manuscript also includes an extract of a letter from John Lorimer to Gauld, 1772, and a sketch of the Middle and Yellow Rivers of West Florida by Thomas Hutchins. When it was received at the APS, it was endorsed: "This long uninteresting Paper can hardly obtain a Place in the Transactions of a Philosophical Society. It should however be preserved in the Files for the Use of Historians or map makers."

The primary correspondence (ca. 65 letters) is with William Cooper (1798-1864) on Bonaparte's publications, especially "American Ornithology" and "Observations on the Nomenclature of Wilson's Ornithology," but also included are many references to American and European men of science and learned societies. There are also letters to Isidore Geoffroy Saint-Hilaire, George Robert Gray, Titian Ramsay Peale, and Wilhelm P. S. Rüppell.

There are botanical notebooks which concern Bunbury's study of fossil plants in general, with special studies on the fossil plants in the Geological Society in Richmond, Virginia, and at Aix-la-Chapelle, Cape Breton Island, and Pennsylvania. There is also a historical sketch of eminent English naturalists.

A key spokesman for the medical establishment against the antivivisection movement, Walter B. Cannon was head of the Council for the Defence of Medical Research of the American Medical Association from 1908 to 1936. He and his colleague William W. Keen monitored antivivisectionist activity, mobilized the medical profession, lobbied politicians, testified in public hearings, and wrote tirelessly in defense of animal experimentation. Cannon was George Higginson Professor of Physiology at Harvard Medical School and head of its physiology department. Keen was a prominent surgeon and neurologist from Philadelphia. The Cannon Papers consist of over 1.5 linear feet of correspondence, 1905-1928, primarily between Cannon (1871-1945) and Keen (1837-1932) regarding their mutual opposition to the antivivisection movement.

The largest portion of correspondence is with Charles Edwin Bessy on botanical matters, including botanical publications in the United States and Europe, and plants and shell specimens.

The first fifteen volumes of these "Notes of Travel" are Lea's account of his trips to Europe during 1832 and 1852-1853. He met with naturalists, scientists, and did much sightseeing in England, France, Germany, Italy, and Austria. He records in detail visits and discussions with scientists, and makes sketches of many of the places he saw, particularly the Rhine River. The sixteenth volume is a memorandum book, 1853, containing accounts and expenses while in Europe.

These are primarily papers relating to the work of the United States Army Corps of Topographical Engineers, with special reference to surveys of harbors of the eastern United States. Some papers and letters relate to natural history and are addressed to John Lawrence LeConte. Correspondents include Rutherford B. Hayes, Joseph Henry, Daniel Parker, and E.G. Squier.