William Clark kept this diary on an expedition to make a treaty with the Osage Indians in the Missouri Territory. A sketch drawn under the September 16 entry is apparently a draft of Clark's Fort Osage map, while the first page of notes presents color scheme used on another draft. See Kate L. Gregg, Westward with Dragoons (1937: 48) for the map in printed version.

The Sketches of a Tour of the Lakes, of the character & customs of the Chippeway Indians & of incidents connected with the treaty of Fond du Lac... to which is super added a vocabulary of the Algic, or Chippeway language... is a record of a journey undertaken by Thomas L. McKenney and Lewis Cass, from Washington, D.C., to Fond du Lac, Wisc., to negotiate a treaty with the Chippewa and other Indians. McKenney, the Superindenant of Indian Affairs, includes an account of travel on the Great Lakes, and more memorably, a description of the "character" and customs of the Chippewa Indians, an account of the treaty of Fond du Lac, and a vocabulary of the Algic or Chippewa language. The manuscript, a fair copy of the original sent to a London publisher, is illustrated throughout with watercolor sketches of scenes and persons. It was originally published in Baltimore in 1827.

This collection includes three journals bound into one volume: two by Willima Dunbar and one by Zebulon Pike. Both manuscripts by William Dunbar document the expedition up the Red and Ouachita Rivers to the Hot Springs of Arkansas in 1804-1805. The "Journal... to the Mouth of the Red River" (200p.) is the fullest available record of the activities of the expedition from the time of their departure from St. Catharine's Landing on October 16, 1804, until their return to Natchez, Miss., on January 26, 1805. The "Journal of a geometrical survey" includes a record of course and distances as well as a thermometrical log and other brief notes. The two are bound together in a volume with Zebulon Montgomery Pike's journal of a voyage to the source of the Mississippi, 1805-1806. The Pike journal documents the expedition to explore the geography of the Mississippi River led by Lt. Zebulon Montgomery Pike in 1805-1806, and his attempts to purchase sites from the Dakota Indians for future military posts, and to bring influential chiefs back to St. Louis for talks. Less a literary masterpiece than a straightforward record in terse military prose, the journal provides a day by day account of the journey and the activities of Pike and his small contingent during this early exploration of present day Minnesota. It was printed with variations and omissions in An Account of Expeditions to the Sources of the Mississippi and through the Western Parts of Louisiana... (Philadelphia, 1810), and was edited in Donald Jackson, ed., The Journals of Zebulon Pike: with Letters and Related Documents (Norman, Okla., 1966).

A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.