A product of the distinctive culture of reform in antebellum Philadelphia, William Parker Foulke was the scion of the old elite who put a conservative stamp on social change. Trained as an attorney, Foulke spent much of his adult life engaging his deep amateur interest in natural history and mental philosophy and devoting himself to a variety of civic and philanthropic causes, including the colonization of formerly enslaved persons, penal reform, and cultural institutions in his native Philadelphia. The Foulke Papers are the product of the diverse social and intellectual interests of the Philadelphia attorney and philanthropist William Parker Foulke. Consisting primarily of correspondence, notes, and essays, the collection touches on Foulke's many interests. The collection includes numerous lectures delivered by Foulke along with material on the Lancaster County Prison, New York Prison Association, and the Philadelphia Society For Alleviating the Miseries of Public Prisons; notebooks concerning prisons and prisoners, including a 1846-1852 diary, and a listing of prisoners, their race, age, crime, sentence, and observations; a diary concerning the American Colonization Society (1852); a copy of an arctic diary (1853-1854) by John Wall Wilson, in the hand of Isaac Israel Hayes, which recounts much of the journey aboard the brig Advance, commanded by Elisha Kent Kane. There is also a list of buildings (1820-1841) designed by John Haviland, and material on the American Academy of Music, Philadelphia.

A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.