Heavily edited, much of this material was used in his lectures on physiology. The section "Of pleasure: Lect: 20th" (ff. 473-477), corresponds word-for-word with some parts of "Two Lectures upon the Pleasures of the Senses and of the Mind," at the end of his "Sixteen Introductory Lectures" (Philadelphia, 1811).

These letters and papers include a memorandum book (1795-1827), lectures on botany and medicine, genealogical materials, committee reports from Columbia College, speeches, minutes of the New York Horticultural Society (1822-1828), letters to Sir James Edward Smith (1817-1826), a receipt book of Alexander Hosack (1781-1801), and diaries of Thomas K. Wharton (1830-1862).