Jane Aitken (1764-1832) is a significant historical figure for several reasons. One of the first American female printers, Jane Aitken was also a bookseller, bookbinder, businesswoman, and employer during the early nineteenth century, a time when the independence of women was actively discouraged. There is a dearth of personal information about Jane Aitken, an unfortunate fact that is reflected in her surviving papers. This small collection, 145 items, is representative of her severely compromised financial situation and her constant failed efforts to rectify the situation. Her correspondence consists primarily of appeals to John Vaughan, a member and librarian of the American Philosophical Society, for loans. Vaughan was evidently a reliable and sympathetic supporter.

A mineralogist and chemist associated with the University of Pennsylvania (1822-1828), William H. Keating was a central figure in the scientific community in Philadelphia during the 1820s and 1830s. Active in the American Philosophical Society and Academy of Natural Sciences, and a founding member of the Franklin Institute, Keating was official geologist on Stephen Harriman Long's expedition to the Great Lakes in 1823 and spent three years in the late 1820s surveying the mineral resources of Mexico. The William H. Keating notebooks include three cash books (daybooks of cash expenditures, 1830-1839) and a book containing surveys of Keating lands in Potter County, most undertaken by Silas McCarty for William's father John Keating (1801-1818). The surveys associated with John Keating are an interesting record of land investment and speculation in the northern tier of Pennsylvania. William Keating's meticulous cash books provide a detailed record of his domestic expenses, philanthropic involvements (donations to the Catholic Church, the Prison Society), his reading (newspapers and books are listed individually), socializing (theatre tickets, Assembly fees), and a variety of miscellaneous expenditures ranging from purchase of a lithograph of Dugald Stewart to a table lamp from C. Cornelius. His accounts also include lists of servant's wages and wages for washerwomen.

George Clymer was a successful merchant, well-known politician, and a generous philanthropist, but is today most famous for being a signer of the Declaration of Independence. As a proponent of independence, he joined various local political committees including six of the seven Philadelphia resistance committees. From there, he entered the national political arena and in 1776 was elected to the Second Continental Congress where he signed the Declaration of Independence. The George Clymer Collection is a small one and not reflective of his varied pursuits. There are twenty-seven documents, most of which are not signed by Clymer; those that are signed by Clymer are dated between May 3, 1800 and January 22, 1813. The items represent not Clymer's political activities but his ordinary legal and real estate transactions.