Principally covering botany and agriculture, this collection includes many manuscripts on trees, shrubs, and plants of different species, copies of botanical essays by others, essays on fruit trees, etc., by Auguste Denis Fougeroux de Bondaroy (1732-89), notes and drafts for the latter's revision of Duhamel's Traité des Arbres et Arbustres. Also miscellaneous essays, sketches, and memoranda on bones of birds and animals, electricity, fish, steam engines, ventilation, temperature and air pressure, mathmatics, paleontology ("Observations sur les os d'éléphants fossiles"), chemistry, metallurgy, entomology, architecture, taxidermy ("Méthode pour empailler les oiseaux"); lists of plants; notes on England, Canada, Mexico, China; notes of reading in Pliny, John Evelyn, Alexander Russell, William Derham, and others. An unpublished translation of Jethro Tull's Horse-Hoeing Husbandry, with additions and revisions by Duhamel du Monceau. An alphabetical catalogue of Duhamel's gardens, prepared by Fougeroux de Bondaroy. The collection has manuscript material in pre-publication form along with published material with marginalia for improvements of later editions. There are a multitude of sketches, botanical materials and seed packets. The collection includes lists of American trees and seeds shared with European scientists. Benjamin Franklin acts as a go between French and American botanists and John Bartram sends seeds to France from his garden. Also correspondence (ca. 170 pieces) with, among others, Peter Collinson, Duc d'Aven, Duc de Noailles, Louis J. M. Daubenton, Mathurin Jacques Brisson, Jean François Gauthier, Comte de La Galissonière, Chrétien Guillaume de Lamoignon de Malesherbes, Emerich Vattel. The collection has been described in part by Gilbert Chinard, "Recently Acquired Botanical Documents," APS Proc. 101 (1957): 508: and by Joseph Ewan, "Fougeroux de Bondaroy (1732-1789) and his Projected Revision of Duhamel du Monceau's Traité (1755) on Trees and Shrubs. I. An Analytical Guide to Persons, Gardens, and Works mentioned in the Manuscripts," APS Proc. 103 (1959): 807.

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.