Catherine Wistar Bache (1805-1886) was the point of connection between two of Philadelphia's most illustrious families of the late eighteenth century. Daughter of the physician Caspar Wistar, in November 1797 she married Dr. William Bache, who was the son of Richard Bache and the grandson of Benjamin Franklin. Primarily letters to Mrs. Bache (wife of Dr. William Bache) of Philadelphia, from Mrs. David Hosack (nee Mary Eddy), Mrs. Elizabeth Trist, and Mary Jones. The letters are personal and concern family life, activities of husbands, etc., with many references to Caspar Wistar, There are comments on diseases, education (at William and Mary College), war, and politics. References are also made to the deaths of Richard Bache and Caspar Wistar, and to Benjamin Franklin's Stockado (a musical instrument).

The Peale family is best known as a family of artists; however, family interests and activities were much more wide-ranging. The best known Peale is Charles Willson Peale (1741-1827, APS 1786), who produced more than one thousand paintings, including hundreds of portraits of leading Americans during the colonial and early national periods. Peale was married three times, to Rachel Brewster (1744-1790), Elizabeth de Peyster (1765-1804), and Hannah More (1755-1821). He had eighteen children, eleven of whom reached adulthood. Three of Charles Willson Peale's sons became artists: Raphaelle Peale (1774-1825), Rembrandt Peale (1778-1860), and Rubens Peale (1784-1865). A fourth son, Titian Ramsay Peale (1799-1885, APS 1833), was a naturalist (who made drawings on the exploring expeditions he accompanied) and pioneer in photography, and another son, Benjamin Franklin Peale (1795-1870), became a naturalist and paleontologist. Peale's daughter Sophonisba Angusciola was married to Coleman Sellers (1781-1834), an inventor and manufacturer of machinery, including locomotives. Two of their sons, George Escol Sellers (1808-1899) and Coleman Sellers (1827-1907, APS 1872), were inventors and engineers. The latter served as director of the construction of the hydro-electric power development at Niagara Falls. He was married to Cornelia Wells Sellers (1831-1909). One of their grandsons was Charles Coleman Sellers (1903-1980, APS 1979), a librarian and historian and the author of several studies of the Peale family, including a Charles Willson Peale biography.

In addition to family and business correspondence, the Charles Nicoll Bancker Family Papers contains various documents, such as a furniture inventory volume (30pp.); a Daybook, 1795-1800 (120pp.); and a very interesting journal (unidentified, but by one of the Banckers, and filed under "Description of a trip..."), from New York to Albany and back, between July 20-Aug. 15, 1793 (1 vol., 31 pp.). It contains detailed observations of the Hudson River and the towns along the way. Bancker was involved in business and trade prior to 1826, and in insurance after that date, so there is material relating to those topics in this collection. He owned a substantial library of the period, which was used by Charles Wilkes's Expedition after 1837 (see Reynell Coates to Bancker). This library, along with Bancker's notable scientific instrument collection, was sold after his death and there are published auction catalogues in the collection. There is much family correspondence from: Anne E. Bancker, Charles Gerard Bancker, Evert Bancker, Sarah U. Bancker, Violetta Bancker Talbot, Elizabeth Bancker Teackle, and John Teackle.