Jasper Yeates (1745-1817) was a lawyer and Pennsylvania Supreme Court justice, one of the state's most successful colonial-era legal practitioners. After moving to Lancaster County in 1765, he became active in colonial and early federal affairs, first by supporting the Revolutionary struggle and later by serving as one of Lancaster's delegates to the State Convention of 1787, which ratified the U.S. Constitution. The Jasper Yeates Papers (1728-1910, bulk 1760-1816) consist mainly of correspondence and business and court/legal records related to the Yeates family. The bulk of this three linear foot collection reflect Yeates' personal life as husband, father, son, and friend, as well as his professional life as lawyer and judge in Pennsylvania; much of the material dated after Yeates' death was created by children and/or grandchildren.

An extensive family collection, the Vaux Family Papers center around the lives of George Vaux V (1721-1803), George Vaux VII (1779-1836), and George Vaux VIII (1832-1915), their business partners, siblings, wives, and children, and encompasses the extended Vaux family of Warders, Sansoms, Heads, Graffs, Morrises, Cressons, and Mayberrys. The collection includes correspondence, financial accounts, receipts, business records, journals, diaries, photographs, and legal documents.

The Scaliger Family Papers, when taken together, trace the history of a noble family that was originally from Italy but lived primarily in Agen, France from the mid-1500s through the mid-1800s. Beginning with the patriarch, Julius Caesar Scaliger (1484-1558), a celebrated Italian scholar and physician, the members of the Scaliger family upheld an illustrious reputation over the centuries as scholars, military leaders, and noblemen. Throughout their family's history, the Scaligers maintained that they were descended from the Della Scallas, Princes of Verona. It is as a result of the necessity to defend this claim as well as later attempts to prove their ties to their noble heritage that this collection of documents has remained so well intact. The Scaliger Family Papers is a collection that encompasses several different kinds of documents that span from 1539 to 1862 including letters, genealogical material, works by members of the Scaliger family, as well as military, legal, and financial documents.