The correspondence (1869-1883) is primarily routine business, i.e. navy orders and letters of recommendation, and also includes some personal letters. In addition, there are several notebooks and diaries, including notes from Pennsylvania Hospital clinical lectures, 1867-1869 (2 v.); diaries, 1865-1875 (7 v.); a volume of poetry; and general study notes. There is also early material (1745-1813) on the Cassin family, including a letter of indenture dated 1758.

The family correspondence of Richard and Sarah Franklin Bache on a variety of topics including references to Benjamin Franklin and his estate. There is also a family genealogy.

The Scaliger Family Papers, when taken together, trace the history of a noble family that was originally from Italy but lived primarily in Agen, France from the mid-1500s through the mid-1800s. Beginning with the patriarch, Julius Caesar Scaliger (1484-1558), a celebrated Italian scholar and physician, the members of the Scaliger family upheld an illustrious reputation over the centuries as scholars, military leaders, and noblemen. Throughout their family's history, the Scaligers maintained that they were descended from the Della Scallas, Princes of Verona. It is as a result of the necessity to defend this claim as well as later attempts to prove their ties to their noble heritage that this collection of documents has remained so well intact. The Scaliger Family Papers is a collection that encompasses several different kinds of documents that span from 1539 to 1862 including letters, genealogical material, works by members of the Scaliger family, as well as military, legal, and financial documents.