These letters and papers include a memorandum book (1795-1827), lectures on botany and medicine, genealogical materials, committee reports from Columbia College, speeches, minutes of the New York Horticultural Society (1822-1828), letters to Sir James Edward Smith (1817-1826), a receipt book of Alexander Hosack (1781-1801), and diaries of Thomas K. Wharton (1830-1862).

This collection contains material relating to his legal affairs, medical publications, receipts for books purchased, and information on botany. Important correspondents include Edward H. Clarke, George Mifflin Dallas, Samuel David Gross, and Joseph Henry. There is also family history in these papers.