APS Member History

Results: 64 Items	Modify Search \| New Search
Page: Prev 1 2 3 4 Next	Reset Page

41	Name:	Robert F. Loeb
	Year Elected:	1951
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1895
	Death Date:	10/21/73

42	Name:	Dr. Michael A. Marletta
	Institution:	University of California, Berkeley
	Year Elected:	2016
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1951

	Michael A. Marletta is on the faculty at the University of California, Berkeley where he holds the CH and Annie Li Chair in the Molecular Biology of Diseases. He is also Professor of Chemistry in the Department of Chemistry and Professor of Biochemistry in the Department of Molecular and Cell Biology at Berkeley. Marletta is a biochemist whose creative work begins with a dissection of a biological question into a molecular framework for study. His primary research interests lie at the interface of chemistry and biology with emphasis on the study of protein function and enzyme reaction mechanisms. His work has demonstrated uncommon creativity and led to remarkable discoveries when asking chemical questions about complex biological phenomena. His work on the enzymes nitric oxide synthase and guanylate cyclase provided many of the fundamental details of nitric oxide signaling that have now become a paradigm for cellular communication involving gases. He has also discovered novel enzymes involved in biomass degradation that also play a role in pathogenesis in humans and plants. Marletta has been recognized with a MacArthur Fellowship (1995), election to the National Academy of Medicine (1999), the American Academy of Arts and Sciences (2001), and the National Academy of Sciences (2006). He has received many awards that recognize his accomplishments including the Harrison Howe Award (2004), the Repligen Award for Chemistry of Biological Processes given by the Biological Chemistry Division of the American Chemical Society (2007), the Emil T. Kaiser Award from the Protein Society (2007), the Gustavus John Esselen Award for Chemistry in the Public Interest, Northeastern Section, American Chemical Society (2007), the American Association of State Colleges and Universities AASCU Distinguished Alumnus Award (2014), the Alfred Bader Award for Bioinorganic/Bioorganic Chemistry (2015), and the UCSF 150th Anniversary Alumni Excellence Award (2015). Marletta serves on editorial boards including the Proceedings of the National Academy of Sciences USA and is a member of the Foundation Board at Fredonia, State University of New York. He was elected a member of the American Philosophical Society in 2016.

43	Name:	Dr. Rowena G. Matthews
	Institution:	University of Michigan
	Year Elected:	2009
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1938

	Rowena G. Matthews is the G. Robert Greenberg Distinguished University Professor of Biological Chemistry and a Research Professor and Charter Faculty Member, Life Sciences Institute at the University of Michigan. She is an internationally recognized authority on the role of folate- and B12-dependent enzymes in homocysteine metabolism and their relevance to disease. Her discoveries define the biochemical basis for establishing guidelines for folate levels in human nutrition. Matthews has also played a major role in the formulation of science policy both nationally and internationally. She was a member of an international advisory panel for the Advanced Study Institutes of NATO from 1994-96, served on the Council of the National Institute of General Medical Sciences from 1991-94, and participated in the activities of the Federal Science Policy Committee on Science of the House of Representatives. Additionally, she won the 2000 William A. Rose Award from the American Society for Biochemistry and Molecular Biology and the 2001 Repligen Award, from the American Chemistry Society. She has been a member of the National Academy of Sciences since 2002 and of the American Academy of Arts & Sciences since 2005.

44	Name:	Dr. William D. McElroy
	Institution:	University of California, San Diego
	Year Elected:	1971
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1917
	Death Date:	2/17/99

45	Name:	Dr. Craig C. Mello
	Institution:	University of Massachusetts Medical School; Howard Hughes Medical Institute
	Year Elected:	2009
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1960

	Craig C. Mello is an Investigator of the Howard Hughes Medical Institute and the Blais University Chair in Molecular Medicine at the University of Massachusetts Medical School. Dr. Mello and his colleague Andrew Fire, Ph.D., of Stanford University, received the 2006 Nobel Prize in Physiology or Medicine for their discovery of RNA interference (RNAi), a natural gene silencing mechanism triggered by double-stranded RNA. RNAi provides both a powerful research tool for knocking out the expression of specific genes and opens a totally unanticipated window on gene regulation. Dr. Mello holds a B.S. in biochemistry from Brown University and a Ph.D. in cellular and developmental biology from Harvard University. He was a postdoctoral fellow at the Fred Hutchinson Cancer Research Center before joining University of Massachusetts Medical School in 1994.

46	Name:	Dr. Daniel Nathans
	Institution:	Howard Hughes Medical Institute, Johns Hopkins University
	Year Elected:	1985
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1928
	Death Date:	11/16/99

47	Name:	Dr. Elizabeth F. Neufeld
	Institution:	David Geffen School of Medicine University of California, Los Angeles
	Year Elected:	1993
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1928

	Elizabeth Neufeld is a leading biochemist responsible for advancing the understanding of the function of the organelles within cells known as lysosomes, which are responsible for the disposal of many molecules that have completed their usefulness to the cell. Dr. Neufeld has made use of inborn defects in lysosomal enzymes and other "experiments of nature" to discover these mechanisms, and in the process she has uncovered methods of diagnosis and management of the disorders that have been of immense benefit to patients. An effective teacher and scientific collaborator, Dr. Neufeld earned her Ph.D. from the University of California, Berkeley in 1956. Currently professor emeritus of biological chemistry at the University of California, Los Angeles School of Medicine, she also worked for many years at the National Institutes of Health. A member of the National Academy of Sciences and the American Academy of Arts & Sciences, Dr. Neufeld is the recipient of awards such as the American Society of Human Genetics' William Allan Award (1982), the Albert Lasker Clinical Medical Research Award (1982) the Wolf Prize in Medicine (1988) and the National Medal of Science (1994).

48	Name:	Dr. Marshall Nirenberg
	Institution:	National Institutes of Health
	Year Elected:	2001
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1927
	Death Date:	January 15, 2010

	Marshall Nirenberg received a Ph.D. at the University of Michigan in 1957. He began his career with the National Institutes of Health in 1957 as a postdoctoral fellow, and joined the staff in 1960. He has been a research biochemist and chief of the Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, at the National Institutes of Health since 1962. Marshall Nirenberg and his coworkers deciphered the genetic code. First, they determined the base compositions of RNA codons by directing cell free protein synthesis with randomly-ordered synthetic polyribonucleotides; then, they determined the nucleotide sequences of RNA codons by directing the binding of aminoacyl-t RNA to ribosomes with trinucleotides of known sequence. They also showed that single-stranded RNA, but not double- or triple-stranded RNA, is a template for protein synthesis. Dr. Nirenberg and his colleagues discovered and characterized Drosophila and mouse homeobox genes. He has focused on one of the Drosophila homeobox genes, vnd-NK-2, which initiates the neural pathway of development in the ventral portion of the neuroectoderm and gives rise to part of the ventral nerve cord. Current studies focus on determining how a pattern of neuroblasts that express the vnd-NK-2 gene is formed in the central nervous system. Dr. Nirenberg, with Robert Holley and Har Khorana, received the Nobel Prize in 1968 for their interpretation of the genetic code and its function in protein synthesis. He is also the recipient of the Molecular Biology Award of the National Academy of Sciences in 1962, the National Medal of Science, Hildebrand Award of the American Chemical Society, Gairdner Foundation Award, Prix Charles Leopold Meyer of the French Academy of Sciences, Franklin Medal of the Franklin Institute, Albert Lasker Award, Priestly Award, and the Louisa Gross Horowitz Prize. Dr. Nirenberg is a member of the American Academy of Arts & Sciences, National Academy of Sciences, and Leopoldina Deutsche Akademie der Naturforscher. He was elected a member of the American Philosophical Society in 2001.

49	Name:	Dr. Severo Ochoa
	Institution:	University of Autonoma, Madrid
	Year Elected:	1961
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1905
	Death Date:	11/1/93

50	Name:	Dr. Baldomero M. Olivera
	Institution:	University of Utah
	Year Elected:	2007
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1941

	Baldomero (Toto) Olivera was born in Manila, studied chemistry at the University of the Philippines, and received his Ph.D. from Caltech in 1966 working with Norman Davidson on the Biophysical Chemistry of DNA. As a post-doctoral fellow at Stanford University with I. R. Lehman, Olivera discovered and characterized E. coli DNA ligase, a key enzyme of replication and recombinant DNA technology. He returned to the Philippines in 1969, where he began to investigate pharmacologically-active peptides ("conotoxins") from the venoms of the predatory cone snails (Conus). Due to the unsettled political situation, he left the Philippines for the University of Utah in 1972 where he is now Distinguished Professor of Biology. There are ~100,000 different conotoxins; these have proven to be important tools for understanding ion channel and receptor function in nervous systems. Several conotoxins discovered in Olivera's lab have therapeutic applications, particularly for alleviating pain; one is an approved drug. Olivera's studies on cone snails have led to his present focus on the molecular and chemical basis of biodiversity.

51	Name:	Dr. Arthur B. Pardee
	Institution:	Dana-Farber Cancer Institute, Harvard University
	Year Elected:	2001
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1921
	Death Date:	February 24, 2019

	Arthur Beck Pardee received his Ph.D. from the California Institute of Technology in 1947. He was an assistant and associate professor at the University of California, Berkeley from 1949-61 and professor of biochemical sciences and Donner Professor of Science at Princeton University from 1961-75. He was a senior postdoctoral fellow at the Pasteur Institute, France from 1957-58 and an American Cancer Society Scholar at the Imperial Cancer Research Fund Laboratory, London, from 1972-73. In 1975 he moved to Cambridge to serve as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Chief of the Division of Cell Growth and Regulation at the Dana Farber Cancer Institute. From 1997 on he was professor emeritus at Harvard. Arthur Pardee's early work was in bacterial biochemistry. His studies on growth regulation led to discoveries of repression of gene transcription, feedback inhibition, and allosteric regulation. He next turned to cancer and identified the restriction point, a major regulatory checkpoint that must be bypassed before cells can initiate DNA synthesis. He demonstrated that an unstable protein must be synthesized for a cell to enter S phase, a process defective in cancer cells. He identified cyclin E as the potential restriction point protein, and factor in growth control at the G1/S boundary. An important technical contribution was the development of "differential display," a method that identifies differences in gene expression in various cells and tissues. Dr. Pardee was a recipient of the Paul Lewis Award of the American Chemical Society, the Sir H. A. Krebs Medal, the Rosensteil Medal, the FASEB 3B Award, the CIT Award, the Boehringer-Mannheim Bioanalytica Award, and the Outstanding Alumnus Award of the California Institute of Technology. He was a member of the National Academy of Sciences, the American Academy of Arts & Sciences, the Japanese Biochemical Society, the American Society of Biological Chemists (president, 1980), and the American Association for Cancer Research (president, 1985). He was member of the Cancer Institute Scientific Committee and served on the scientific board of the Worcester Foundation. He was elected a member of the American Philosophical Society in 2001. Arthur Pardee died February 24, 2019 at the age of 97.

52	Name:	Dr. Alexander Rich
	Institution:	Massachusetts Institute of Technology
	Year Elected:	1980
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1924
	Death Date:	April 27, 2015

	Alexander Rich was a preeminent researcher in structural molecular biology. He joined the faculty of the Massachusetts Institute of Technology in1958, and he had been the William Thompson Sedgwick Professor of Biophysics. Best known for the discovery of left-handed DNA, or Z-DNA, and the three-dimensional structure of transfer RNA, he was also one of the leading workers in the determination of structure and function of Z-DNA binding proteins by x-ray crystallographic and other methods. Dr. Rich received his M.D. from Harvard University Medical School in 1949 and was a founder and director of the pharmaceutical development company Alkermes, Inc. He was awarded the 1995 U.S. National Medal of Science, the 2000 Bower Award for Excellence in Science and the 2009 Welch Award in Chemistry, among other honors, and he has been elected to the National Academy of Sciences and the Institute of Medicine. He was elected a member of the American Philosophical Society in 1980. Dr. Rich died April 27, 2015, at the age of 90, in Boston, Massachusetts.

53	Name:	Dr. Frederic M. Richards
	Institution:	Yale University
	Year Elected:	1992
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1925
	Death Date:	January 11, 2009

	A pioneer in crystallography and structural biology, Frederic M. Richards has been Sterling Professor Emeritus of Molecular Biophysics and Biochemistry at Yale University since 1991. He received his Ph.D. from Harvard University in 1952 and, aside from a year in Copenhagen with Linderstrom Lang and a year in Cambridge with A.C. Chibnell, he has spent his entire academic career at Yale, chairing the department of molecular biology, biophysics and chemistry from 1969-73. A member of the National Academy of Sciences and the American Academy of Arts & Sciences, Dr. Richards has received honors such as the Pfizer-Paul Lewis Award in Enzyme Chemistry (1965), the Kai Linderstrom-Lang Prize in Protein Chemistry (1978) and the American Society for Biochemistry and Molecular Biology-Merck Award (1988). An intellectual leader, Dr. Richards is admired not only for his meticulous science, which has relevance to many fields, but for his generous, open and warm scientific style.

54	Name:	Dr. Paul Schimmel
	Institution:	The Scripps Research Institute
	Year Elected:	1999
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1940

	Paul Schimmel is the Ernest and Jean Hahn Professor of Molecular Biology and Chemistry at The Scripps Research Institute. He received his Ph.D. at Massachusetts Institute of Technology and remained on the faculty of MIT until 1997. Dr. Schimmel is the recipient of the Pfizer Award in Enzyme Chemistry from the American Chemical Society and is an elected member of the National Academy of Sciences and American Academy of Arts & Sciences. Dr. Schimmel has contributed extensively to the understanding of the protein-RNA interactions that are the basis of the universal genetic code. He showed how features in small RNA structures are interpreted as specific amino acids referred to by some as a "second genetic code." Most recently he established how RNA structure plays an essential role in enhancing the accuracy of the genetic code by an error correction mechanism. Also, in other work, Nature magazine cited his development of "expressed sequence tags" as one of the four key developments that launched the human genome project. Author or co-author of 400 scientific papers and of a widely used three-volume textbook on biophysical chemistry, Dr. Schimmel has also applied basic biomedical research to human health. For example, his laboratory discovered human proteins active in blood vessel formation, developed them, and brought them to clinical medicine. He holds several patents and is cofounder or founding director of ten biotechnology companies, of which 5 are publicly traded. These companies are developing new therapies for human disease. He was elected to the American Philosophical Society in 1999.

55	Name:	Dr. Maxine F. Singer
	Institution:	Carnegie Institution of Washington & National Institutes of Health
	Year Elected:	1990
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1931

	Maxine Frank Singer has made major contributions to the biochemistry of nucleic acids and more recently to our knowledge of the mammalian genome structure and organization. She has also served with distinction as chair of the editorial board of the Proceedings of the National Academy of Sciences and as president of the Carnegie Institution, and she is widely recognized as an articulate author and spokesperson for science. After receiving her Ph.D. in biochemistry from Yale University in 1957, Dr. Singer joined the research staff of the National Institutes of Health. She would later serve as chief of the Laboratory of Biochemistry at the National Cancer Institute from 1980-87, where she led fifteen research groups engaged in various biochemical investigations. Dr. Singer's research contributions have ranged over several areas of biochemistry and molecular biology, including chromatin structure, the structure and evolution of defective viruses, and enzymes that work on DNA and its complementary molecule, RNA. In recent years, her foremost contributions have been in studies of a large family of repeated DNA sequences called LINES - sequences interspersed many times in mammalian DNA. She and her co-workers have been especially interested in the LINE-1 sequence, which is repeated thousands of times in human DNA. LINE-1, she early concluded, is capable of insertion into new places on chromosomal DNA, and researchers elsewhere later found that LINE-1 insertions into a gene whose product is required for blood clotting are associated with cases of hemophilia. Believing that the mechanism of LINE-1 transposition might have broad significance for understanding genetic diseases, Dr. Singer and her colleagues have concentrated their experiments on learning how LINE-1 elements move. Throughout her career, Dr. Singer has assumed leading roles in influencing and refining the nation's science policy. In 1988 she became President of the Carnegie Institution of Washington, where she led the biologists, astronomers and earth scientists who make up the Institution's six scientific departments. Dr. Singer is presently President Emerita of the Carnegie Institution while also retaining her association with the National Cancer Institute as Scientist Emerita. Her several awards for public service include the Distinguished Presidential Rank Award (1988) and the National Medal of Science (1992), the nation's highest scientific honor bestowed by the President of the United States, "for her outstanding scientific accomplishments and her deep concern for the societal responsibility of the scientist." Most recently, she was honored with the 2007 Public Welfare Medal, the National Academy of Sciences' most prestigious award recognizing extraordinary use of science for the public good.

56	Name:	Dr. Emil L. Smith
	Institution:	University of California, Los Angeles
	Year Elected:	1973
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1911
	Death Date:	May 31, 2009

	Emil L. Smith is Professor of Biological Chemistry Emeritus at the University of California, Los Angeles, where he has served on the faculty of the School of Medicine since 1963. One of the world's leading authorities on the amino acid sequences of proteins and on biochemical evolution, his research has dealt with photosynthesis; chlorophyll; physiology of the visual process; proteolytic enzymes; glycoproteins; cytochrome; histones; and glutamate dehydrogenases. An outstanding leader in biochemical research and a man of broad scientific interests, Dr. Smith earned his Ph.D. from Columbia University in 1937. He subsequently worked as a Guggenheim Fellow at Cambridge and Yale and as a research associate at the Rockefeller Institute (1940-42) and as a biophysicist at E.R. Squibb & Company's Biological Laboratories (1942-46) before joining the faculty of the University of Utah (1946-63). From 1959-62 Dr. Smith also served as chairman of the United States National Committee on Biochemistry. A member of the National Academy of Sciences, he is the author (with A. White, P. Handler and others) of Principles of Biochemistry, for seven editions (1954-83) one of the leading textbooks in the field.

57	Name:	Dr. Donald F. Steiner
	Institution:	University of Chicago; Howard Hughes Medical Institute
	Year Elected:	2004
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1930
	Death Date:	November 11, 2014

	Donald F. Steiner was born in Lima, Ohio in 1930. He received his M.D. degree from the University of Chicago in 1956 and had a distinguished career at the university as professor of biochemistry (1968-70); A. N. Pritzker Professor of Biochemistry and Medicine (1970-84); chairman of the department of biochemistry (1973-79); director of the Diabetes-Endocrinology Center (1974-78); associate director of the Diabetes and Research Training Center (1977-81); and A. N. Pritzker Distinguished Service Professor of Biochemistry & Molecular Biology and Medicine (1984-2014). He has also been a senior investigator in the Howard Hughes Medical Institute (1985-2006) and director or co-director of the University of Chicago Diabetes and Research Training Center. In 1967 Dr. Steiner discovered proinsulin, the single-chain precursor of insulin. He purified it and studied its structure, properties, biosynthesis, and cell biology, demonstrating its intracellular conversion into insulin and the cosecreted C-peptide. With Dr. A. H. Rubenstein, radioimmunoassays were developed for proinsulin and C-peptide in serum, which have been widely applied in diabetes research. Dr. Steiner's pioneering studies thus opened the now very broad field of precursor protein processing, leading to the identification of many other proproteins and more recently to the discovery of the mammalian proprotein convertase family of cellular processing endoproteases. His laboratory also first demonstrated receptor-mediated uptake and degradation of insulin. His discoveries have strongly influenced insulin and islet cell research, ranging from the commercial production of human insulin for diabetes therapy to the evolution of insulin and insulin-like growth factors (IGFs). The recipient of honors including the Gairdner Award (1971), Wolf Foundation Prize in Medicine (1985) and the Endocrine Society's Fred C. Koch Award (1990), Dr. Steiner was a member of the National Academy of Sciences and the American Academy of Arts & Sciences. He was elected a member ofthe American Philosophical Society in 2004. Donald Steiner died November 11, 2014, at age 84 at his home in Chicago, Illinois.

58	Name:	Dr. Joan A. Steitz
	Institution:	Yale University & Howard Hughes Medical Institute
	Year Elected:	1992
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1941

	Joan A. Steitz is Sterling Professor of Molecular Biophysics and Biochemistry at Yale University as well as an investigator at the Howard Hughes Medical Institute. She has made important research contributions to the study of the role of small nuclear RNAs (snRNAs) in eukaryotic cells, and she is credited with discovering that complexes containing these snRNAs reacted specifically with sera from autoimmune patients. She then recognized that sequences in one of these snRNAs were complementary to sequences important in splicing of RNA in the nucleus of cells. This hypothesis proved correct and played a critical role in directing the field. Dr. Steitz is the recipient of prestigious awards such as the Eli Lilly Award in Biological Chemistry (1982), the National Medal of Science (1987), the Dickson Prize for Science (1989), the Cristopher Columbus Discovery Award in Biomedical Research (1992), the Lewis S. Rosenstiel Award (2002), the Albany Medical Center Prize in Medicine and Biomedical Research (2008), the Connecticut Medal of Science (2015), the William Clyde DeVane Medal (2016), and the Wolf Prize in Medicine (2021). A graduate of Antioch College (B.S., 1963) and Harvard University (Ph.D., 1967), she was elected to the membership of the American Academy of Arts & Sciences in 1982 and the National Academy of Sciences in 1983.

59	Name:	Dr. Jack W. Szostak
	Institution:	Howard Hughes Medical Institute; Harvard Medical School; Massachusetts General Hospital
	Year Elected:	2012
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Living
	Birth Date:	1952

	Dr. Jack W. Szostak is an Investigator of the Howard Hughes Medical Institute, Professor of Genetics at Harvard Medical School, and the Alex Rich Distinguished Investigator in the Dept. of Molecular Biology and the Center for Computational and Integrative Biology at Massachusetts General Hospital. Dr. Szostak is a member of the National Academy of Sciences, and a Fellow of the New York Academy of Sciences, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science. Dr. Szostak’s early research was on the genetics and biochemistry of DNA recombination, which led to the double-strand-break repair model for meiotic recombination. At the same time Dr. Szostak made fundamental contributions to our understanding of telomere structure and function, and the role of telomere maintenance in preventing cellular senescence. For this work Dr. Szostak shared, with Drs. Elizabeth Blackburn and Carol Greider, the 2006 Albert Lasker Basic Medical Research Award and the 2009 Nobel Prize in Physiology or Medicine. In the 1990s Dr. Szostak and his colleagues developed in vitro selection as a tool for the isolation of rare functional RNA, DNA and protein molecules from large pools of random sequences. His laboratory has used in vitro selection and directed evolution to isolate and characterize numerous nucleic acid sequences with specific ligand binding and catalytic properties. For this work, Dr. Szostak was awarded, along with Dr. Gerald Joyce, the 1994 National Academy of Sciences Award in Molecular Biology and the 1997 Sigrist Prize from the University of Bern. In 2000, Dr. Szostak was awarded the Medal of the Genetics Society of America, and in 2008 Dr. Szostak received the H.P. Heineken Prize in Biophysics and Biochemistry. Dr. Szostak’s current research interests are in the laboratory synthesis of self-replicating systems and the origin of life.

60	Name:	Dr. Paul Talalay
	Institution:	Johns Hopkins University
	Year Elected:	1990
	Class:	2. Biological Sciences
	Subdivision:	201. Molecular Biology and Biochemistry
	Residency:	Resident
	Living? :	Deceased
	Birth Date:	1923
	Death Date:	March 10, 2019

	Paul Talalay, M.D. was John Jacob Abel Distinguished Service Professor of Pharmacology and Molecular Sciences at Johns Hopkins University School of Medicine. He held an S.B. degree in biophysics from M.I.T. and an M.D. degree from Yale. Following surgical training at Massachusetts General Hospital, he moved to the University of Chicago, rising to the academic ranks of Professor of Biochemistry, Professor of Medicine, and Professor in the Ben May Laboratory for Cancer Research. After serving for 12 years as Director of the Department of Pharmacology at Johns Hopkins Medical School, he relinquished this position to devote himself full time to research. Dr. Talalay devoted his career to cancer research. For more than 2 decades he was involved in devising strategies for chemoprotection against the risk of cancer, a field in which he is recognized as a pioneer. His efforts focused on achieving protection by raising the enzymes concerned with the detoxication of carcinogens. Analysis of the chemistry and the molecular biology of boosting enzymes of detoxication led him and his colleagues to devise simple cell culture methods for detecting chemical and especially dietary (Phyto)chemicals that raise these enzymes. This work led to the isolation of sulforaphane as the most potent inducer of protective enzymes in broccoli. These findings, published in the Proceedings of the National Academy of Sciences, attracted world-wide attention, and led to the organization of the Brassica Chemoprotection Laboratory at Johns Hopkins. This unique laboratory is exclusively dedicated to identifying edible plants that are particularly rich in protective enzyme-inducer activity. Dr. Talalay's honors, in addition to his appointment as a University Distinguished Service Professor, included appointment to one of the first lifetime professorships of the American Cancer Society and membership in the National Academy of Sciences and the American Academy of Arts & Sciences. He published more than two hundred papers in internationally respected scientific journals. He received an honorary D.Sc. degree from Acadia University. The M.D.-Ph.D. Student Library at Johns Hopkins has been named in his honor. He was elected a member of the American Philosophical Society in 1990. Paul Talalay died March 10, 2019 in Baltimore, MD at the age of 95.

Page: Prev 1 2 3 4 Next