American Philosophical Society
Member History

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2. Biological Sciences[X]
181Name:  Herbert Fox
 Year Elected:  1932
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1881
 Death Date:  2/26/1942
   
182Name:  Thomas Francis
 Year Elected:  1954
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1900
 Death Date:  10/1/1969
   
183Name:  Edwin Broun Fred
 Year Elected:  1945
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1887
 Death Date:  1/15/81
   
184Name:  Dr. Donald S. Fredrickson
 Institution:  National Library of Medicine & National Institutes of Health & Howard Hughes Medical Institute
 Year Elected:  1985
 Class:  2. Biological Sciences
 Subdivision:  204. Medicine, Surgery, Pathology and Immunology
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1924
 Death Date:  June 7, 2002
   
185Name:  Dr. Elaine Fuchs
 Institution:  Rockefeller University; Howard Hughes Medical Institute
 Year Elected:  2005
 Class:  2. Biological Sciences
 Subdivision:  202. Cellular and Developmental Biology
 Residency:  Resident
 Living? :   Living
 Birth Date:  1950
   
 
Elaine Fuchs is a world leader in mammalian cell biology. She is internationally recognized for her outstanding and numerous contributions to skin biology and its human genetic disorders, including skin cancers and life-threatening genetic syndromes such as blistering skin disorders. For nearly three decades, Dr. Fuchs has focused on the molecular mechanisms that underlie development and differentiation of the epidermis and its appendages, and elucidating how perturbations of these mechanisms result in disease. She has systematically and brilliantly applied innovative approaches in biology, biochemistry and genetics. In doing so, Dr. Fuchs pioneered the use of "reverse genetics," an approach to start with a specific protein, study its biology and then use mice as a means to ultimately identify the genes responsible for inherited human disorders. A classical geneticist would start with a specific genetic disorder. Instead, Dr. Fuchs has employed this innovative cell biological approach to determine the genetic bases of numerous dermatological disorders in humans. The approach has since broadly benefited human medical genetics. Dr. Fuchs is widely recognized as having brought the field of dermatological research into modern day science. Her contributions are many, ranging from the identification of proteins and signal transduction pathways important in epidermal and hair functions to uncovering the molecular nature of skin diseases in humans. In addition, Dr. Fuchs and coworkers identified genetic defects in several disorders that arise from perturbations of cytoskeletal proteins related to those present in the skin, but whose expression resides outside the skin, particularly in the muscle and the nervous system. An elegant example of this is her use of reverse genetics to uncover the underlying genetic basis of blistering human skin disorder that arises from defects in epidermal keratin genes. Dr. Fuchs' 10 years of prior research set the groundwork for this discovery, which uncovered a key function of intermediate filament (IF) proteins as mechanical integrators of the cytoskeleton. The work also set the paradigm for more than 20 different human disorders of IF genes. Dr. Fuchs' ground-breaking research is often used in biology and medical textbooks as a landmark. Her science now focuses on understanding how tissues develop and dynamically respond to their environment. She has seamlessly transitioned from problems of signal transduction to transcriptional regulation and gene expression to the cytoskeleton and adhesion to stem cell lineage commitment. In the nineties, her team uncovered multiple roles for Wnt signaling in skin biology, discovering that sustained Wnt signaling can lead to stem cell activation and tumorigenesis. Their super-furry mice led them to identify stabilizing b-catenin mutations pilomatricomas, a human skin tumor. While b-catenin mutations had been previously linked to colon cancer, pilomatricomas represented the first example where b-catenin mutations are the leading cause of the tumor. Similarly, Dr. Fuchs' work on a-catenin provided insights into squamous cell carcinoma. The lab's transition from degenerative disorders to cancers has been a natural one, occurring concomitantly with their shift to tackling how growth and differentiation are balanced in stem cell lineage progression. Their recent work in isolating and characterizing the multipotent adult skin stem cells opens major new avenues for their future research in this area. Elaine Fuchs received her undergraduate degree with highest distinction in chemistry from the University of Illinois, Urbana-Champaign (1972). She received her Ph.D. in biochemistry from Princeton University (1977) and conducted her postdoctoral studies with Howard Green at the Massachusetts Institute of Technology, where she began her research in skin biology. She joined the faculty at the University of Chicago in 1980, where she progressed to become Amgen Professor of Basic Sciences prior to leaving for Rockefeller University in 2002, where she is Rebecca C. Lancefield Professor. She has been an Investigator of the Howard Hughes Medical Institute since 1988. Dr. Fuchs is a member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts & Sciences. She was President of the American Society of Cell Biology in 1991, and she holds an honorary doctorate from Mt. Sinai and New York University School of Medicine. Her scientific awards include the Richard Lounsbery Award (National Academy of Sciences), the Cartwright Award (Columbia University), the Novartis Award in Biomedical Research, the Dickson Prize in Medicine, the National Medal of Science, the 2010 L'Oreal-UNESCO prize, the 2012 March of Dimes Prize in Developmental Biology, the 2015 E. B. Wilson Medal, the 2016 Vanderbilt Prize in Biomedical Science, the 2019 AACR-G.H.A. Clowes Memorial Award, and the 2020 Canada Gairdner Award. She has trained more than 20 graduate students and has over 225 publications to her credit. Elaine Fuchs was elected a member of the American Philosophical Society in 2005.
 
186Name:  Dr. Fred H. Gage
 Institution:  Salk Institute for Biological Studies
 Year Elected:  2010
 Class:  2. Biological Sciences
 Subdivision:  208. Plant Sciences
 Residency:  Resident
 Living? :   Living
 Birth Date:  1950
   
 
Fred H. Gage received his Ph.D. at Johns Hopkins University in 1976. He is president and professor in the Laboratory of Genetics at the Salk Institute for Biological Studies, and Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases. In January 2019 the the Board of Trustees of the Salk Institute coted to extend his term as President through 2024. Gage's work concentrates on the adult central nervous system and unexpected plasticity and adaptability to environmental stimulation that remains throughout the life of all mammals. His work may lead to methods of replacing or enhancing brain and spinal cord tissues lost or damaged due to Neurodegenerative disease or trauma. Gage's lab showed that, contrary to accepted dogma, human beings are capable of growing new nerve cells throughout life. Small populations of immature nerve cells are found in the adult mammalian brain, a process called Neurogenesis. Gage is working to understand how these cells can be induced to become mature functioning nerve cells in the adult brain and spinal cord. They showed that environmental enrichment and physical exercise can enhance the growth of new brain cells and they are studying the underlying cellular and molecular mechanisms that may be harnessed to repair the aged and damaged brain and spinal cord. Several of his numerous prizes and awards include the IPSEN Prize for Neuroplasticity, the Charles A. Dana Award, Metropolitan Life Research Award, the Keio Medical Science Prize, and the ARCS Scientist of the Year award. He is President of the International Society for Stem Cell Research. He is a Fellow of the American Association for the Advancement of Science, a Member of the National Academy of Sciences and the Institute of Medicine, and the American Academy of Arts and Sciences; an Associate Member of the European Molecular Biology Organization. He was elected a member of the American Philosophical Society in 2010.
 
187Name:  Dr. D. Carleton Gajdusek
 Institution:  CNRS Institut Alfred Fessard
 Year Elected:  1978
 Class:  2. Biological Sciences
 Subdivision:  209. Neurobiology
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1923
 Death Date:  December 11, 2008
   
 
A physician and medical researcher, Daniel Carleton Gajdusek was the co-recipient, along with Baruch Blumberg, of the 1976 Nobel Prize in Physiology or Medicine for his groundbreaking study of the disease Kuru. He is known for establishing the role of "slow viruses" in human disease, espeically of the nervous system. In addition to his studies of kuru in New Guinea, he has extensively studied Creutzfeld-Jakob disease in Europe and the Americas. Born in Yonkers, New York in 1923, Dr. Gajdusek obtained his M.D. from Harvard University in 1946 and performed postdoctoral research at both Harvard and the California Institute of Technology. He studied virus and rickettsial diseases at the Pasteur Institute in Tehran, Iran from 1954-55 and became head of laboratories for virological and neurological research at the National Institutes of Health (NIH) in 1958. He was inducted into the National Academy of Sciences in 1974.
 
188Name:  Dr. Joseph Grafton Gall
 Institution:  Carnegie Institution of Washington
 Year Elected:  1989
 Class:  2. Biological Sciences
 Subdivision:  202. Cellular and Developmental Biology
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1928
 Death Date:  9/12/2024
   
 
Joseph Gall is an outstanding cytogeneticist known for his research on the organization and structure of genes along animal chromosomes and for developing methods for detecting individual genes on chromosomes. He is a co-discoverer of gene amplification, which was later found to be an important concomitant of some cancers. Dr. Gall received his Ph.D. from Yale University in 1952 and has taught at the University of Minnesota and at Yale University, where he was Ross Granville Harrison Professor of Biology and Professor of Molecular Biophysics and Chemistry from 1964-83. He has been a staff member in the department of embryology at the Carnegie Institute of Washington since 1983 and American Cancer Society Professor of Developmental Genetics since 1984. He is a member of the American Academy of Arts & Sciences and the National Academy of Sciences and was awarded the American Society for Cell Biology's E.B. Wilson Medal in 1983. A scholar of the history and use of microscopes and a collector of scientific books, especially those relating to cytology, Dr. Gall is a true naturalist with an encyclopedic knowledge and curiosity about living things.
 
189Name:  Herbert Spencer Gasser
 Year Elected:  1937
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1888
 Death Date:  5/11/1963
   
190Name:  William J. Gies
 Year Elected:  1915
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1872
   
191Name:  Dr. Philip D. Gingerich
 Institution:  University of Michigan
 Year Elected:  2010
 Class:  2. Biological Sciences
 Subdivision:  203. Evolution & Ecology, Systematics, Population Genetics, Paleontology, and Physical Anthropology
 Residency:  Resident
 Living? :   Living
 Birth Date:  1946
   
 
Philip Gingerich is Ermine Cowles Case Professor of Paleontology and Professor of Geological Sciences, Biology, and Anthropology at the University of Michigan. Dr. Gingerich received his Ph.D. from Yale University in 1974 and joined the University of Michigan faculty the same year. He has been director of the University of Michigan Museum of Paleontology since 1981. Dr. Gingerich studies evolutionary history in the context of environmental change, focusing on the Paleocene-Eocene transition 55 million years ago, the diversification of primates, and the evolution of whales from land to sea. He has directed more than 50 empirical field expeditions in Egypt, Pakistan, and Wyoming. His Egyptian study area at Wadi Hitan is now a UNESCO world heritage site. Dr. Gingerich developed methods for quantifying and comparing evolutionary rates, unifying our understanding that evolution is fast and populations change rapidly in response to natural selection. He is a member of the American Academy of Arts and Sciences (2001), recipient of the André Dumont Medal of the Belgian Geological Society (2005), the recipient of the Romer-Simpson Medal of the Societ of Vertebrate Paleontology (2012), and was elected a member of the American Philosophical Society in 2010.
 
192Name:  Dr. Donald A. Glaser
 Institution:  University of California, Berkeley
 Year Elected:  1997
 Class:  2. Biological Sciences
 Subdivision:  201. Molecular Biology and Biochemistry
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1926
 Death Date:  February 28, 2013
   
 
Donald Glaser had been an institution at the University of California, Berkeley, where he was Professor of Physics and Professor of Neurobiology in the Graduate School. He was awarded the 1960 Nobel Prize in Physics for his invention of the bubble chamber detector of subatomic particles. This device played a critical role in the flowering of experimental particle physics in the sixties and seventies. In later years Dr. Glaser turned his research interests to the psychophysics of visual perception, to which he has made several significant contributions. His research goal was to construct computational models of the human visual system that explain its performance in terms of its physiology and anatomy. A member of the National Academy of Sciences and the Royal Society, Dr. Glaser was a man with broad scientific and cultural interests, not least among them being, as a former member of the Cleveland Orchestra's string section, his professional-level musicianship. Donald Glaser died February 28, 2013, at the age of 86 at his home in Berkeley, California.
 
193Name:  Dr. H. Bentley Glass
 Institution:  State University of New York, Stony Brook
 Year Elected:  1963
 Class:  2. Biological Sciences
 Subdivision:  207. Genetics
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1906
 Death Date:  January 16, 2005
   
194Name:  Dr. Laurie H. Glimcher
 Institution:  Dana Farber Cancer Institute; Harvard Medical School
 Year Elected:  2019
 Class:  2. Biological Sciences
 Subdivision:  209. Neurobiology
 Residency:  Resident
 Living? :   Living
 Birth Date:  1951
   
 
Laurie H. Glimcher is President and Chief Executive Officer of the Dana-Farber Cancer Institute and Richard and Susan Smith Professor of Medicine at Harvard Medical School. She earned her M.D. from Harvard Medical School in 1976, where she spent most of her career, including as Irene Heinz Given Professor of Immunology. Laurie Glimcher has elucidated the molecular pathways that regulate the development and activation of cells in the immune system - pathways critical for both the development of protective immunity and for the pathophysiologic immune responses underlying autoimmune, infectious, allergic, and malignant diseases. She discovered the first Th1-specific transcription factor, T-bet, and demonstrated that it is the master-regulator of Type 1 immunity in cells of both the adaptive and innate immune system. She also discovered XBP1, the first transcription factor required for both plasma cell differentiation and the Endoplasmic Reticulum (ER) Stress Response. She then demonstrated a link between ER stress and proinflammatory/autoimmune diseases. Most recently she discovered that XBP1 is key in the maintenance of cancer stem cells in triple negative breast cancer. Further, IRE1/XBP1 also controls anti-tumor immunity by disrupting dendritic cell homeostasis. Hence reducing IRE1/XBP1 activity should simultaneously inhibit tumor cell growth and activate type 1 anti-tumor immunity. She is a member of the American Academy of Arts & Sciences (1996), the National Academy of Sciences (2002), and the American Association of Immunologists, (president, 2003-04). Laurie Glimcher was elected a member of the American Philosophical Society in 2019.
 
195Name:  David Rockwell Goddard
 Year Elected:  1954
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1908
 Death Date:  7/9/1984or5
   
196Name:  Dr. Joseph L. Goldstein
 Institution:  University of Texas Southwestern Medical Center
 Year Elected:  1987
 Class:  2. Biological Sciences
 Subdivision:  201. Molecular Biology and Biochemistry
 Residency:  Resident
 Living? :   Living
 Birth Date:  1940
   
 
Joseph Goldstein is currently Chairman of the Department of Molecular Genetics at the University of Texas Southwestern Medical Center at Dallas and Julie and Louis A. Beecherl, Jr. Distinguished Chair in Biomedical Research and Paul J. Thomas Chair in Medicine. In 1985, he was named Regental Professor of the University of Texas. Together with his colleague Dr. Michael S. Brown, Dr. Goldstein has received a number of awards for their discovery of receptors that control cholesterol metabolism, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), National Medal of Science (1988) and Albany Medical Center Prize in Medicine and Biomedical Research (2003). Dr. Goldstein is a member of the U.S. National Academy of Sciences, American Philosophical Society, and the Institute of Medicine. He is also a Foreign Member of the Royal Society (London) and has received Doctor of Science honorary degrees from numerous institutions, including University of Chicago, University of Paris and The Rockefeller University. Dr. Goldstein is a past president of the American Society for Clinical Investigation (1985-86) and was a member of the Governing Council of the U.S. National Academy of Science (1991-94). He was also a Non-Resident Fellow of the Salk Institute (1983-1994) and served as Chairman of the Medical Advisory Board of the Howard Hughes Medical Institute (1995-2002). He has also served as a member of the editorial boards of Cell, Annual Review of Genetics, Journal of Biological Chemistry, Arteriosclerosis, Science and the Proceedings of the National Academy of Science. Dr. Goldstein is currently Chairman of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University. He is a member of the Scientific Advisory Boards of the Welsh Foundations, Memorial Sloan-Kettering Cancer Center, Van Andel Institute, and the Dana-Farber Cancer Institute. He also currently serves on the Scientific Advisory Boards of several biotechnology companies (Genentech, Armgo, Five Prime) and is a member of the Board of Directors of Regeneron Pharmaceuticals.
 
197Name:  Dr. Corey S. Goodman
 Institution:  venBio Partners LLC; University of California, Berkeley
 Year Elected:  1999
 Class:  2. Biological Sciences
 Subdivision:  208. Plant Sciences
 Residency:  Resident
 Living? :   Living
 Birth Date:  1951
   
 
Corey Goodman was named president of Pfizer's Biotherapeutics and Bioinnovation Center in 2007. Prior to this appointment, he was president and CEO of Renovis, a neuroscience biopharmaceutical company he helped co-found in 2000. Dr. Goodman received his B.S. degree in biology from Stanford University in 1972, and his Ph.D. degree in neurobiology from the University of California, Berkeley in 1977. From 1977 to 1979 he was a Helen Hay Whitney Postdoctoral Fellow at U.C. San Diego. Beginning in 1979 he was a faculty member in the Department of Biological Sciences at Stanford University, receiving tenure in 1982. In 1987 he joined the faculty at the University of California at Berkeley, where he was an Investigator with the Howard Hughes Medical Institute, Evan Rauch Professor of Neuroscience, and Director of the Wills Neuroscience Institute. Dr. Goodman is a world leader in the understanding of the molecules and mechanisms that control nerve growth and guidance, and their implications for nerve restoration and repair. In 2001, he became President and CEO of Renovis. He is also President of the McKnight Endowment Fund for Neuroscience, and Chair of the National Research Council's Board on Life Sciences. Prior to co-founding Renovis, Dr. Goodman co-founded Exelixis in 1994. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society. Amongst his many scientific honors is the Alan T. Waterman Award for Achievement in Medical Sciences in 1997, and the March-of-Dimes Prize in Developmental Biology in 2001.
 
198Name:  Ermest William Goodpasture
 Year Elected:  1943
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1887
 Death Date:  9/ /1960
   
199Name:  Dr. Jeffrey I. Gordon
 Institution:  Washington University School of Medicine
 Year Elected:  2014
 Class:  2. Biological Sciences
 Subdivision:  209. Neurobiology
 Residency:  Resident
 Living? :   Living
 Birth Date:  1947
   
 
Jeffrey Gordon is the Dr. Robert J. Glaser Distinguished University Professor at Washington University in St. Louis. He received his A.B. from Oberlin College and his M.D. from the University of Chicago. He joined the Washington University faculty after completing his clinical training in internal medicine and gastroenterology, and doing post-doctoral research at the NIH. He was Head of the Department of Molecular Biology and Pharmacology from 1991-2004 before becoming the founding Director of a University-wide, Center for Genome Sciences and Systems Biology. His lab’s interdisciplinary studies of the genomic and metabolic foundations of mutually beneficial host-microbial relationships in the human gut have helped create a new field of research that focuses on understanding of the role of our microbial communities in shaping postnatal development, health status and disease predispositions. Gordon's work has provided an extended view of ourselves as a composite of species from all three domains of life, where genes in our gut microbial community genomes (microbiomes) endow us with attributes we have not had to evolve on our own. His group has developed new experimental and computational approaches to characterize the assembly and dynamic operations of human gut communities; this work has involved studies of gnotobiotic animal models, twins concordant or discordant for physiologic phenotypes, and children and adults representing diverse geographic, cultural and socio-economic conditions. A central issue he and his students have addressed and continue to pursue is how our gut microbiomes contribute to obesity and to childhood undernutrition. Their findings concerning how our gut microbiomes determine the metabolic, physiologic and immunologic effects of the various foods we consume are altering the way healthy diets can be defined, providing new views of how our changing lifestyles impact health, revealing how functional maturation of the microbiome is related to healthy growth of infants and children, and helping to usher in a new era of microbiome-directed therapeutics. Gordon has been the research mentor to 120 PhD and MD/PhD students and post-doctoral fellows since he established his lab at Washington University. Recently, working with colleagues in Bangladesh, Gordon has developed therapeutic foods designed to support and nurture the development of a healthy gut microbiome in the first few years of life. A new therapeutic food was shown to repair defective microbial community development in children with malnutrition and restore their growth toward a normal trajectory. Jeffrey Gordon is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Inventors, and the Institute of Medicine of the National Academies. He is the recipient of the Robert Koch Award from the Koch Foundation, the Selman A. Waksman Award in Microbiology from the National Academy of Sciences, the Passano Laureate Award from the Passano Foundation, and the Dickson Prize in Medicine. In 2015 he was awarded the Keio Medical Science Prize, in 2017 the Horwitz Prize and the Sanofi-Institut Pasteur International Award, in 2018 the British Royal Society's Copley Medal, and in 2021 the Kober Medal and the Balzan Prize. He was elected a member of the American Philosophical Society in 2014.
 
200Name:  Evarts Ambrose Graham
 Year Elected:  1941
 Class:  2. Biological Sciences
 Residency:  Resident
 Living? :   Deceased
 Birth Date:  1884
 Death Date:  3/4/1957
   
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