| 1 | Name: | Dr. Arthur B. Pardee | |
| Institution: | Dana-Farber Cancer Institute, Harvard University | ||
| Year Elected: | 2001 | ||
| Class: | 2. Biological Sciences | ||
| Subdivision: | 201. Molecular Biology and Biochemistry | ||
| Residency: | Resident | ||
| Living? : | Deceased | ||
| Birth Date: | 1921 | ||
| Death Date: | February 24, 2019 | ||
Arthur Beck Pardee received his Ph.D. from the California Institute of Technology in 1947. He was an assistant and associate professor at the University of California, Berkeley from 1949-61 and professor of biochemical sciences and Donner Professor of Science at Princeton University from 1961-75. He was a senior postdoctoral fellow at the Pasteur Institute, France from 1957-58 and an American Cancer Society Scholar at the Imperial Cancer Research Fund Laboratory, London, from 1972-73. In 1975 he moved to Cambridge to serve as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Chief of the Division of Cell Growth and Regulation at the Dana Farber Cancer Institute. From 1997 on he was professor emeritus at Harvard. Arthur Pardee's early work was in bacterial biochemistry. His studies on growth regulation led to discoveries of repression of gene transcription, feedback inhibition, and allosteric regulation. He next turned to cancer and identified the restriction point, a major regulatory checkpoint that must be bypassed before cells can initiate DNA synthesis. He demonstrated that an unstable protein must be synthesized for a cell to enter S phase, a process defective in cancer cells. He identified cyclin E as the potential restriction point protein, and factor in growth control at the G1/S boundary. An important technical contribution was the development of "differential display," a method that identifies differences in gene expression in various cells and tissues. Dr. Pardee was a recipient of the Paul Lewis Award of the American Chemical Society, the Sir H. A. Krebs Medal, the Rosensteil Medal, the FASEB 3B Award, the CIT Award, the Boehringer-Mannheim Bioanalytica Award, and the Outstanding Alumnus Award of the California Institute of Technology. He was a member of the National Academy of Sciences, the American Academy of Arts & Sciences, the Japanese Biochemical Society, the American Society of Biological Chemists (president, 1980), and the American Association for Cancer Research (president, 1985). He was member of the Cancer Institute Scientific Committee and served on the scientific board of the Worcester Foundation. He was elected a member of the American Philosophical Society in 2001. Arthur Pardee died February 24, 2019 at the age of 97. | |||