John Lyon's botany journal offers a record of travels in the eastern U.S. at the turn of nineteenth century. The volume includes memoranda dated 1799, with entries spanning 9/6/1802-8/6/1814. Lyon's entries document expenses—plants purchased and collected—with occasional notes about the places and peoples he encounters. Entries related to his travels in the eastern and southeastern U.S. record a visit to plantations (4/23/1803), an Indian settlement in Georgia (7/19/1803), and medical treatments for palsy, jaundice, and cancer (12/1/1808). Notably, Lyon discusses an albino slave in Athens, Georgia, as excerpted in Selected Quotations (9/25/1804). In the spring of 1806, he records travel to Dublin, Liverpool, and London. Thus, while the Lyon journal will certainly appeal to researchers exploring nineteenth century botany, they also feature content with wider appeal, such as U.S. slavery, transatlantic travel, indigenous trade, and antebellum medicine.