F. H. (Frank Henry) Pike Papers, circa 1922-1952


Date: 1922-1952 | Size: 7 Linear feet


This collection contains correspondence (approximately 150 letters), subject files, and notes on various research projects. The various subject areas include the central nervous systems, brains, and physiologies of many animals. Included are some anatomical drawings.

Background note

Frank Henry Pike (1876-1953) was a neurophysiologist who taught for thirty years in the Department of Physiology of the College of Physicians and Surgeons of Columbia University. He made significant contributions to the studies of the physiology of the nervous system and physiological psychology.

Pike was born in Aurora, Illinois on January 20, 1876. He was the eighth child of William Dana Pike and Maria Wilmoth Pike. He spent much of his youth on the family farm near Plainfield, Illinois. At age 15, he and a brother drove a wagon west to Montrose, Colorado, where they homesteaded for two years. Afterwards, Pike began his collegiate studies, studying at Valparaiso and Indiana Universities. He received his Bachelor of Science degree from the latter institution in 1903.

Pike then pursued a Ph.D. at the University of Chicago, specializing in the physiology of respiration. There, he studied under A. G. Mathews. Earning a doctorate in 1907, for the next four years he taught physiology at Chicago.

In 1911, Pike was hired as assistant professor in the Department of Physiology of the College of Physicians and Surgeons of Columbia University. This began a thirty-year official association with Columbia. He retired as a full professor in 1941, afterwards serving as a special lecturer until his death.

In addition to studying and teaching physiology, Pike maintained an interest in physics and was equally at home in all of the sciences. He sought to relate other fields of science to physiology through his teaching. He espoused the importance of comparative physiology. His chief interest was discovering how the nervous system worked.

Pike married Susan Hattie Reece (1871-1943) on June 24, 1907. Together, they had one child, Eugene Wilmoth Pike (1909-1980).

Pike died on November 13, 1953.

Collection Information

Physical description

7 linear feet.


Presented by Mrs. Rook Metzger McCulloch and accessioned, 04/29/1970 (1970 657ms).

Related material

The Hofstra University Library contains some of Frank Pike's professional papers. They are part of the Matthew N. Chappell Collection at the University Archive. Chappell was a former student and protege of Pike.

Indexing Terms


  • Drawings.

Personal Name(s)

  • Adams, Charles C. (Charles Christopher), 1873-1955
  • Donaldson, Henry Herbert, 1857-1938
  • Hektoen, Ludvig, 1863-1951
  • Pike, F. H. (Frank Henry), 1876-1953
  • Riddle, Oscar, 1877-1968
  • Shapley, Harlow, 1885-1972


  • Brain.
  • Central nervous system.
  • Medical sciences.
  • Physiology -- Research.
  • Zoology.

Detailed Inventory

I. Correspondence
Adams, Charles C. (Charles Christopher), 1873-1955
American Association of University Women
Andrus, William De Witt, 1896-1951
Association for Research in Nervous and Mental Disease
Babak, Eduard, 1873-1926


Bakance, Charles
Barbour, Henry G. (Henry Gray), 1886-1943
Behre, Chas. H. (Charles H.), 1896-1986
Berry, Frank W.
Birkhoff, George David, 1884-1944
Blanshard, Brand, 1892-1987
Bott, Edward Alexander, 1887-1974
Burchell, Samuel C., 1897-1986
Cannon, Walter B. (Walter Bradford), 1871-1945
Carmichael, Leonard, 1898-1973
Cathcart, John Philip Selby, 1890-1973

Includes letter to J. S. Rogerson

Cattell, James McKeen, 1860-1944
Cheney, Clarence Orion, 1887-1947
Cobb, Stanley, 1887-1968
Columbia University
Darby, Hugh H. (Hugh Hackland), b. 1895
Detlefsen, J. A. (John Adolph), 1883-1936
Donaldson, Henry Herbert, 1857-1938
Dresden, Arnold, 1882-1954
Dusser de Barenne, J. G. (Joannes Gregorius), 1885-1940
Elsberg, Charles A. (Charles Albert), 1871-1948
Emerson, Alfred E. (Alfred Edwards), 1896-1976
Fischer, Martin, 1879-1962
Gregory, William H.
Guild, Stacy Rufus, 1890-1966
Harrington, Milton, 1884-1942
Hawkes, Herbert E. (Herbert Edwin), 1872-1943
Hawley, Amos Henry, 1910-2009
Heilbrunn, L. V. (Lewis Victor), 1892-1959
Hektoen, Ludvig, 1863-1951
Hooker, -----
Hunt, Reid, 1870-1948
Huskins, C. Leonard (Charles Leonard), 1897-1953
Hyman, Harold Thomas, 1894-1985
Indiana University. Alumni Office
Jones, Isaac H. (Isaac Hampshur), 1881-1956
Lawton, Shailer Upton, 1894-1966
Loring, Marguerite G.
Lyon, Elias Potter, 1867-1937
MacKinnon, -----
Magnus, R. (Rudolf), 1873-1927
Mast, S. O. (Samuel Ottmar), 1871-1947
Max, Louis William, 1901-1995
Maxwell, Samuel Steen, 1860-1939
Miller, Heymen Rudolph, b. 1888
Morris, Robert T. (Robert Tuttle), 1857-1945
Moulton, Forest Ray, 1872-1952
Muschenheim, Carl, 1905-1977
National Committee for Mental Hygiene
National Research Council
National Research Council. Vestibular Research Committee
National Roster of Scientific and Specialized Personnel
Nelsen, T. G.
Noble, G. Kingsley (Gladwyn Kingsley), 1894-1940
Northrop, F. S. C. (Filmer Stuart Cuckow), 1893-1992
Notkin, J.
Palmer, W. W.
Papez, James W. (James Wenceslas), 1883-1958
Pike, Eugene Wilmoth, 1909-1980
Price, George McCready, 1870-1963
Putnam, Tracy Jackson, 1894-1975
Radachy, Esther, 1904-1985
Rappleye, Willard C. (Willard Cole), 1892-1976
Renner, D. S.
Riddle, Oscar, 1877-1968
Rough, Roberts
Salway, Elizabeth
Shand, S. James (Samuel James), 1882-1957
Shapley, Harlow, 1885-1972
Sinnott, Edmund W. (Edmund Ware), 1888-1958
Sollman, Torald Herman, 1874-1965
Stefano, James J., 1893-1955
Stewart, John Quincy, 1894-1972
Tati, John
Terman, Lewis M. (Lewis Madison), 1877-1956
Tilney, Frederick, 1875-1938
Trueblood, Charles K.
Wendt, G. Richard (George Richard), 1906-1977
Williams, N. B.
Wilson, J. Gordon, 1858-1948
Winker, Cora S.
Wolff, Harold G. (Harold George), 1898-1962
II. Subject Files
Abstracts of Papers
Adaptional Factors in the Origin and Development of the Lungs

Formerly titled "On Adaptional Factors in the Origin and Development of the Lungs"

Afferent Conduction in the Cranial Nerves
Afferent-Efferent Relationships in the Central System
Afferent Nerve Notes
Afferent System
Afferent System, Analysis Of
American Medical Association Questionaire
Anatomical Drawings
Anxiety Neurosis is of Automatic Origin
Apparatus for Studying Visual Pattern Discrimination in the Cat
Approach to Symbiosis or Parasitism in Nerve Cell and Sheath Cell
Approach to the Study of the Physiology of the Central Nervous System of Vertebrates
Aristotle Pneuma (Jaeger and von Bonn)
Atrophy and Degeneration in Inactive Cells
Biographical Material
Bromides in Experimentally Produced Convulsions
Can any Mechanism be Devised
Cerebellum Lesions

Formerly titled "On Cerebellum Lesions"

Combined Lesions of the Decussations of the Pyramidal Tracts
Carmichael Leonard, 1898-1973.
Concerning Functional Organization of Nervous System
Conduct of Impulses within the Central Nervous System
Conduction in the Central System

Preface to book? Formerly titled "Some General Comment on Conduction in the Central System."

Cranial Nerves

Formerly titled "Concerning Cranial Nerves."

Decerebrate Rigidity

Formerly titled "Concerning Decerebrate Rigidity"

Definition of Life
Development of the Ideas of Functional Organization of the Nervous System of Vertebrates in More Recent Years
Development of the Various Theories of Functional Organization of the Nervous System Subsequent to the Early Work of Jackson
Diaphragmatic Hernia in Cats

Two cases

Diary Notes and Pictures of Cats
Disorderly Movements of Chorea and Convulsions

Formerly titled "Concerning Disorderly Movements of Chorea and Convulsions"

Effect of Potassium and of Cardiac Glucosides on the Vagus Reactions of the Turtle's Heart and Stomach

Formerly titled "Concerning Epilepsy"

Equipment Design Drawings
Ethics and Scientific Thought

Formerly titled "Concerning Ethics and Scientific Thought"

Evolution and Saving of Work as Shown in the Respiratory Mechanism
Evolution - Nervous System in Deuterostomia
Evolution of the Nervous System

Includes folder formerly titled "Concerning Evolution of the Nervous System"

Experimental Convulsions

Following Lesions of the Corpus Striatium

Experiments, Results of
Foerster, Otfrid, 1873-1941. Gage, O..
On the Clinico-Patho-Physiologico-Anatomical Studies...Column in Man
From Goltz to Steiner: The Period of the Ascendancy of Schock
Functional Origin of the Nervous System
Fundamental Adjustments of Living Organisms to the Formal Conditions of Existence
General Data of the Physiology of the Nervous System
General Status of Constructive Scholarship and its Needs in America

Includes correspondence

Ground Work of Physiology

Includes lecture material


Formerly titled "Concerning Hybernation"

Hypotheses: Some Comments and Some Characteristics
Influence of Parathyroid Hormone on Certain Joint Disturbances and Other Conditions
Journal of Comparative Neurology
Last Illness of Sue R. Pike

Formerly titled "Concerning Last Illness of Sue R. Pike"

Laws of Physiology
Limitations of the Method of Conditioned Reflex
Lipschutz, Alexander, 1883-1980.
Sexual Glands and their Action
Longet's Treatise on Physiology


Mechanism and the Biological Sciences
Metabolism of a Nerve Fiber

Formerly titled "Concerning Metabolism of a Nerve Fiber"


Formerly titled "Concerning Mimicry"

Mind and the Conservation of Energy
Moll Galvanometer
Nature of a Law of Science

Lecture material

Nature of Mind
Nature of Nervous Reactions

Formerly titled "Concerning Nature of Nervous Reactions"

Nerve Cells
Nerves, by Various Writers

Formerly titled "On Nerves, by Various Writers"

Nervous Reactions

Formerly titled "On Nervous Reactions"

Nervous System

Formerly titled "Concerning the Nervous System"

Neural Bases of Behavior
Neurological Experiments and Notes

Formerly titled "Concerning Neurosis"

Newspaper Clippings
Notkin, J..
Intravenous Pharmacodynamic Study of the Vegetative Nervous System in the Cryptogenic Group of Convulsive State
Ocular Muscle Imbalance and Afferent Impulses from the Muscle: Fatigue in Reading
Olivary System Material
Organization of the Mind
Origin and Evolution of Polyzoa
Origin and Evolution of the Nervous System - Bryozoa
Origin of the Central Nervous System
 2 folders
Origin of the Nervous System of Vertebrates

Formerly titled "On the Origin of the Nervous System of Vertebrates"

Origin of Vertebrate Nervous System

Formerly titled "Concerning Origin of Vertebrate Nervous System"

Outlines and Notes on Physiology

Formerly titled "Concerning Personality"

Physical Basis of Mind

Abstracts and comments

Physiological Properties
Physiology and Experimental Science

Lecture material

Physiology of the Central Nervous System of Vertebrates
 5 folders
Physiology of the Central Nervous System of Vertebrates
Physiology of the Central Nervous System of Vertebrates ... of Organic Evolution
Physiology of the Central Nervous System of Vertebrates. Outline
Physiology of the Central Nervous System of Vertebrates. Preface
Physiology of the Central Nervous System of Vertebrates. Rough Notes
Physiology: Thermodynamic Aspects

Lecture material

Point and the Line
Possible Relationship between the Current of Injury and the White Blood Cell in Inflammation
Problem of Functional Organization in the Central Nervous System of Vertebrate Animals

See separate gray box

Problems of Organic Evolution Considered from the Point of View of Physiology

Formerly titled "Some Problems of Organic Evolution Considered from the Point of View of Physiology"

Procedures Used in Semantic Conditioning
Pruritis Ani

Formerly titled "Concerning Pruritis Ani"

Psychogenic Origin

Formerly titled "Concerning Psychogenic Origin"


Formerly titled "Concerning Psychology"

References on the Nervous System
Relation of the Atmosphere to Plants, Animals, and to Man
Relation of Man to his Environment
Respiration and Oxidation

Formerly titled "Concerning Respiration and Oxidation"

Role of Certain Hormones in Organic Synthesis
Rose: Balance and Disturbance of Balance in the Autonomic Nervous System
Some Considerations from General Biology which Affect the Study of the Nervous System
Spinal Column Sketches
Spinal Cord of Plagiostomea

Rough notes

 2 folders

Formerly titled "Concerning Stars" and "On Stars"

Surface Tension

Formerly titled "Concerning Surface Tension"

 2 folders

One folder was formerly titled "Concerning Thermodynamics"

Turck, Fenton B. (Fenton Benedict), 1857-1932.
Breakdown of Metabolism and the Organs of Metabolism in the Alimentary Tract
Type of Nerve Cell Concerned in a Particular Function
Underlying Thermodynamic Factors in Evolution
III. Notes
 3 boxes
IV. Graphics
 1 box

Photographs, tracings, etc.