This volume contains medical notes by Wistar, including observations on yellow fever and arguments to prove its foreign origin, facts relative to the progress of the fever in 1797, the infection and death of Colonel Van Emburgh, the infection of the crew of the ship "Deborah" and of the Durham boat (1802), an account of the diseases which afflicted the family of James Hammar in Montgomery County (Pa.), facts relating to the typhus fever of 1812-1813, case histories (1796-1803), temperature chart (1758-1759, 1760), and a thermometrical journal (1760-1765) kept by Charles Norris and copied by Wistar from notes in possession of Joseph Parker Norris.

Reel one contains account books, including Agness Minshall (1784-1810), Jacob Minshall (1773-1818), Enos Painter (1802-1863), Minshall Painter (1842-1873), and John J. Tyler (1890-1910). Reel two contains almanacs, receipts, and bank books of Jacob Minshall (1843-1877), Enos Painter (1852-1854), Minshall Painter (1840-1873), and John J. Tyler. Reel three contains day books for Minshall Painter and Jacob Minshall, Mathew Carey's "Account of the Yellow Fever Epidemic," Society of Friends burial records for the Middletown Friends' Meeting graveyard (1787-1859), and complaints against the Painter family (1699-1807), genealogies of the Dutton family, Painter family, Tyler family, Minshall family, and Gilpin family, and journals of travels of John J. Tyler (1841-1900). Reel four contains miscellaneous records on observations of the Liberal File (1853-1856) and a women's rights meeting (1851), an essay by Oran Hazard on slavery (1796), taxes for the Enos Painter estate (1864-1873), and travel guides of the United States and Canada (1844, 1874). Reels five and six contain the shelf list cards for the John J. Tyler Arboretum Library.

Having made his fortune as a goldsmith and silversmith, John Leacock (1729-1802) became one of Philadelphia's most energetic entrepreneurs in viticulture and a playwright and parodist in the cause of American Independence. Despite bearing the title, "Observations, Experiments etc. extracted from the Philosophical Transactions respecting farming, gardening, etc.," the notebook kept by the silversmith, viticulturist, and writer, John Leacock, is actually a combination of commonplace book, notebook, and receipt book. Consisting of 58 folio pages, the book contains a hodgepodge of entries reflecting Leacock's varied interests from 1768 through at least 1781, including not only material copied from other sources on viticulture, agriculture, engraving and etching, but medicinal and culinary receipts and two original poems, a "Song [of] the Stamp Act" and "A parody on the Tempest, by R. H. Esq." It also mentions diet drinks made by James Logan and Cadwallader Evans.

This is primarily a collection of letters and manuscripts sent to Wistar by prominent men who were among his many correspondents. These documents reflect his broad interests, including botany, paleontology, medicine, the American Philosophical Society, and André Michaux's plans for exploring the Missouri.

An extensive family collection, the Vaux Family Papers center around the lives of George Vaux V (1721-1803), George Vaux VII (1779-1836), and George Vaux VIII (1832-1915), their business partners, siblings, wives, and children, and encompasses the extended Vaux family of Warders, Sansoms, Heads, Graffs, Morrises, Cressons, and Mayberrys. The collection includes correspondence, financial accounts, receipts, business records, journals, diaries, photographs, and legal documents.

A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.

This rich collection of letters and documents, which was assembled by Sol Feinstone (1888-1980) over a period of fifty years, includes material on almost all notable Americans from before the Revolution to the 1850's, as well as prominent Europeans, and there are documents relating to military affairs. There are substantial groups of letters from: John Adams, Henry Dearborn, Alexander Hamilton, Jedediah Huntington, Thomas Jefferson, Lafayette, George Washington, and a long run of letters from a Massachusetts military surgeon named Samuel Adams. Many letters, though written by Revolutionary figures, relate to events that occurred before or after the War.