These papers include letters, reports, accounts, and memoranda relating to the work of the American Board of Home Missions among the Abnaki, Cherokee, Chickasaw, Choctaw, Creek, Dakota, Mackinaw, Maumee, Mayhaw, Ojibwa, Osage, Pawnee, Penobscot, Sioux, and Stockbridge Indians of Arkansas, New York, and Oregon.

These papers include letters, reports, minutes, memoranda, and addresses to Indian chiefs, selected from the Pickering papers from the Massachusetts Historical Society. Includes letters and documents pertaining to Pickering, Henry Knox, John Sergeant, Jasper Parrish and Samuel Kirkland; relates to New York and Western Indian affairs, principally Iroquois, but also Nanticoke, Shawano, Delaware, Wyandot, Miami, Seneca.