This correspondence is principally concerned with business between Pershouse and his brother James in England, with comments on conditions and events in the United States, including anti-British feeling, Thomas Paine's return to America, Jefferson's administration, and immigration. The papers include Pershouse's journal (1800-1838), which includes accounts of travels in England, France, and the United States, letterbooks (1836-1862) of Henry Pershouse, nephew of John, chiefly on business matters, and two volumes of Pershouse genealogical data, compiled by B.M. Pershouse Bayley (1899).