This item is a detailed description of the geography, population, natural resources, and agriculture of the Ouachita River area of the Louisiana Territory. Describes mounds; mentions Cataoulou Indians; also gives figures as to numbers of white and Indian hunters. These pages are a record of travel on a road built between Choctaw and Chickasaw country, with comments on the condition of Indian-white relations, the increase in white population, and Wilson's stay, at Muscle Shoals, with Cherokee chiefs Doublehead and Skiowska. Wilson finds the Indians have good farms, furnishings, fences, and stock, and one Indian runs an inn.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.