This collection contains correspondence and reports and documents Florence Seibert's work at Yale University, under Lafayette Benedict Mendel; at the University of Chicago, under H. Gideon Wells; and at the Henry Phipps Institute at the University of Pennsylvania, 1932-1959. There are cancer research folders concerning her later work at the Mound Park Hospital Foundation and the Bay Pines V. A. Center, in St. Petersburg, Florida. There are also substancial amounts on Goucher College (her alma mater); Lilly Research Laboratories; Merck, Sharpe & Dohme; and Parke, Davis & Company.

This collection is primarily correspondence and also notes on experiments concerning the cytology research of Lewis and his wife, Dr. Margaret Reed Lewis, at Johns Hopkins University, Carnegie Institution of Washington, and finally at the Wistar Institute of Anatomy and Biology in Philadelphia. There is significant material relating to his professional society activity in the American Association of Anatomists (President, 1934-1936) and the International Society for Experimental Cytology.

Eugene Opie spent most of his career as a pathologist at the Rockefeller Institute engaged in research on the influenza, tuberculosis, blood diseases, poliomyelitis, and viruses. His work at Washington University, St. Louis, is documented, as are his efforts to alleviate tuberculosis in Jamaica, among Philadelphia schoolchildren, and in New York City. The Opie collection contains correspondence, notebooks, lab notes from his days at Rockefeller, articles, reprints, and photographs. Opie's long interest in China is reflected in material on the American Bureau for Medical Aid to China, the United China Relief, and Chinese medicine in general. There is also significant documentation on the International Health Division of the Rockefeller Foundation, the Henry Phipps Institute of the University of Pennsylvania, the Milbank Memorial Fund, and other institutions. There are also reports of approximately 300 clinical autopsies performed at the Base Hospital, Camp Pike, Ark., of soldiers who died in the flu epidemic of 1918. Also there are notes of Opie's course in pathology at the University of Pennsylvania.

Simon Flexner, born in 1863, one of the nation's leading experts in pathology and bacteriology, was most renowned for his research on cerebrospinal meningitis, polio and infantile paralysis. Arguably though, Flexner's stewardship of the Rockefeller Institute was his greatest contribution to medical and scientific research. His rise in the medical community began in the late nineteenth century in Louisville, Kentucky, where despite not having completed even the seventh grade, Flexner taught himself basic bacteriology by conducting experiments at home using a microscope borrowed from the pharmacy where he served as an apprentice. Granted a medical degree from the University of Louisville School of Medicine in 1889, he went on to a pathology fellowship at the newly opened John Hopkins School of Medicine. Within two short years of leaving Louisville, Flexner received an assistant of pathology appointment at Johns Hopkins. It was a quick ascent and the beginning of a long and brilliant career that included a prestigious appointment at the University of Pennsylvania and then a directorship at the new Rockefeller Institute where he realized his lifelong dream of creating a dynamic and productive research laboratory. The Rockefeller Institute became instantly famous worldwide as the preeminent research facility for virology and under Flexner's direction produced invaluable contributions in pathology, bacteriology, and immunology. This collection does not reflect the early phases of Flexner's career at Johns Hopkins but does document an early interest in meningitis and other infectious diseases with science-related correspondence, laboratory notebooks, and administrative correspondence with the New York City and State Departments of Health. There is abundant material on Flexner's directorship of the Rockefeller Institute for Medical Research, including Flexner's search for staff, an involved process which is detailed in correspondence with the scientists, many of whom became quite famous. Also included is material relating to the other institutions and Rockefeller philanthropies with which Flexner was involved. (Among the most significant correspondence, however, may be that which documents the support of the General Education Board and the Rockefeller Foundation in the development and subsequent reorganization of medical schools following brother Abraham Flexner's scathing report on medical education in the United States and Canada). This collection would be of great interest to anyone interested in the history of bacteriology, histology, and immunology or the general history of modern medicine and philanthropy.