Alexander Hollaender was a leading researcher on the genetic effects of radiation. Born in Samter, Germany, in 1898 and arriving in the United States in 1921, Hollaender was educated at the University of Wisconsin, receiving his AB, MA, and Ph.D. there. He served on the faculty at the University of Tennessee and the University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences. He was director of the division of biology at the Atomic Energy Commission's Oak Ridge National laboratory from 1946 until 1966. The 4 linear feet of the Alexander Hollaender Papers contain incoming and outgoing correspondence and reports relating to the genetic effects of radiation, specifically atomic radiation. Also included are documents of the International Conference on the Peaceful Uses of Atomic Energy; the NAS Committee on the Biological Effects of Atomic Energy, Genetics Panel; the United Nations Scientific Committee on Atomic Radiation; and the World Health Organization all of which Hollaender was closely involved with.

A bacteriologist from MIT, Salvador E. Luria's work with Max Delbruck on bacteriophage demonstrated that bacterial resistance to certain phages arose through genetic mutations. His later work showed that phages also mutate genetically. He received the Nobel Prize in Physiology or Medicine in 1969 with Max Delbruck and Alfred D. Hershey. The collection is organized into seven series: I. Correspondence, 1938-1992 ; IIa. Subject Files, 1938-1990 ; IIb. Personal Material. 1923-1991 ; III. Works by Luria, 1938-1987 ; IV. Works by Others, 1944-1990 ; V. Research Notes and Notebooks, 1941-1979 ; VI. Course Material, 1931-1991 ; VII. Photographs and Negatives, 1957-1982. Arrangement: Alphabetical by folder title and then chronological within each folder.