These papers include letters, reports, accounts, and memoranda relating to the work of the American Board of Home Missions among the Abnaki, Cherokee, Chickasaw, Choctaw, Creek, Dakota, Mackinaw, Maumee, Mayhaw, Ojibwa, Osage, Pawnee, Penobscot, Sioux, and Stockbridge Indians of Arkansas, New York, and Oregon.

These selections include letters, bills, accounts, receipts, memoranda, and official communications and documents relating to the Iroquois in New York state, selected from volumes 6-15 of O'Reilly's collections, "Mementos of western settlement," together with copies of documents from the American State Papers, etc. Included are letters of Phelps, Gorham, Chapin, Brant, Kirkland, Knox, Pickering, Irvine, and Morris. Many manuscripts appear to be from the papers of General Israel Chapin, an Indian agent.