The maize geneticist Barbara McClintock (1902-1992) is credited with the discovery of "jumping genes," that is chromosomal "crossing over" and translocation. She received the Nobel Prize in Physiology or Medicine in 1983. The collection is organized into six series: I. Correspondence, 1931-1991; II. Subject files, 1938-1989; III. Works by McClintock, 1944-1989; IV. Works by others, 1927-1991; V. Research notes, notebooks, and card files, 1930s-1990s ; VI. Photographs, 1928-1991.

Mostly concerned with Blakeslee's studies on beans, blood groups, colchicine, Datura, embryo cultures, and horticulture. Many letters relate to the support and direction of the Smith College Genetics Experiment Station, which he headed. Other letters are about the Carnegie Institution of Washington, "Biological Abstracts," American Association for the Advancement of Science, American Philosophical Society, Institut de France, University of Connecticut. Also contains travel letters from Germany and miscellaneous lectures.

A bacteriologist from MIT, Salvador E. Luria's work with Max Delbruck on bacteriophage demonstrated that bacterial resistance to certain phages arose through genetic mutations. His later work showed that phages also mutate genetically. He received the Nobel Prize in Physiology or Medicine in 1969 with Max Delbruck and Alfred D. Hershey. The collection is organized into seven series: I. Correspondence, 1938-1992 ; IIa. Subject Files, 1938-1990 ; IIb. Personal Material. 1923-1991 ; III. Works by Luria, 1938-1987 ; IV. Works by Others, 1944-1990 ; V. Research Notes and Notebooks, 1941-1979 ; VI. Course Material, 1931-1991 ; VII. Photographs and Negatives, 1957-1982. Arrangement: Alphabetical by folder title and then chronological within each folder.

The geneticist Milislav Demerec emigrated from Yugloslavia in 1919, spending nearly his entire career in the Department of Genetics at Cold Spring Harbor Laboratory. Working initially on the genetics of maize and later on Drosophila virilis, his research interests included radiation and chemical mutagenesis, and during the Second World War, penicillin and the genetics of antibiotic resistance. Demerec served as head of the laboratory at Cold Spring Harbor from 1941 until 1960. The Demerec collection contains the extant professional papers of Milislav Demerec, dating primarily from the time of his arrival at Cold Spring Harbor until his retirement. In addition to his correspondence with colleagues, the collection includes interesting material on the administration of Cold Spring Harbor laboratory during the 1940s and 1950s, data and research notes, material relating to professional organizations (e.g. Genetics Society of America, American Society of Naturalists), a lengthy series of lectures given by Demerec, and a large number of photographs pertaining to Demerec's research, but also to his colleagues and Cold Spring Harbor itself. There is also a Register of visitors to the laboratory (1927-1945) and a Milislav Demerec reprint list.

Ernst Wolfgang Caspari was an important contributor to behavior and developmental genetics, working primarily on the mealmoth Ephestia. Trained in Alfred Kuhn's laboratory at the University of Göttingen (1933-1935), Caspari was forced from his position by the Nazis in 1933, escaping to the United States five years later. As a professor of biology at Lafayette College, Wesleyan University, and the University of Rochester, Caspari continued his research on Ephestia, mouse genetics, and behavior genetics until his retirement in 1975. The Caspari Papers includes correspondence, papers, grant reports, and lectures relating to Caspari's genetic research dating primarily from the period after his departure from Germany. In addition to substantial material on behavior genetics and human evolution, the collection includes correspondence relating to Caspari's editorial work for Advances in Genetics, and his involvement with the American Institute of Biological Sciences, the Center for Advanced Study in the Behavioral Sciences, Cold Spring Harbor Laboratory, Fifth Banff Conference on Theoretical Psychology, Genetics Society of America, International Conference on the Unity of Science, Social Science Research Council, Committee on Genetics and Behavior, and the U.S. Atomic Energy Commission.

The James V. Neel Papers document nearly every phase of the career of one of the founders of human population genetics in the United States. Neel was particularly thorough and organized, and retained virtually all of his significant scientific correspondence, committee reports, minutes of meetings, and drafts of manuscripts. The collection also includes data collected during Neel's work among the Xavante, Yanomanö and other indigenous populations. In a career that spanned the period from the late work of Thomas Hunt Morgan and Charles B. Davenport to the contemporary world of molecular genetics and nucleic acids, Neel knew, worked with, and corresponded with many of the most influential 20th century practitioners of genetics. The collection begins in earnest in 1943, after Neel had decided to focus on human genetics. Neel's work with Drosophila and none of his Drosophila manuscripts are found in the collection.