The Clayton Papers are a highly selective collection of Clayton's correspondence, research notes, and miscellaneous data, emphasizing her work on Drosophila. Her teaching and administrative commitments at the University of Arkansas are documented. Her work with Hampton L. Carson on the Hawaiian Drosophila Project is well represented with slides, notes, and specimens.

This collection includes correspondence, manuscripts (lectures and articles), research grant material, research data, and participation in organizations, such as, the American Society of Naturalists (President, 1968), Genetics Society of America (President, 1963), and the National Research Council. Of particular note, are the detailed data related to Drosophila eye pigment, and human chromosomes.

This collection of correspondence, reports, and manuscripts concerns Stalker's research in genetics and evolutionary biology, particularly the evolutionary genetics of Drosophila. Most of the letters are scientific, although the usual academic politics in various departments is mentioned. There is also material on the Society for the Study of Evolution (1970).