The Smith-Houston-Morris-Ogden Family Papers document the history of the Houston, Smith, Ogden, Morris and allied families, beginning in the late 17th century, and continuing through to near the end of the 20th. Among the many treasures in this vast collection are the papers of Pennsylvania Railroad executive Henry Howard Houston (1820-1895), his son, Samuel Frederick Houston (1866-1952), and of Pennsylvania attorney and treasury official, William Meredith (1752-1816). Although the collection contains a great deal of interest with respect to land speculation, commerce, and trade emanating from Philadelphia, the bulk of the Smith Family Papers consists of personal and family correspondence and other papers. Among the largest and most interesting bodies of papers are those of L.M.C. Smith and Eleanor Houston Smith, daughter of Samuel F. Smith. These document the family's progressive attitudes regarding and resource conservation, historic preservation, and their social activism. This very large collection includes much material that is not itemized below.

The collection of about 850 items covers the period from 1782 to c. 1936, with the bulk dating to the 1780s to 1840s. The collection is divided into four series. Series I contains correspondence relating to a wide variety of topics, including French and English politics, business, trade, religious matters, and personal affairs. Many of the items are letters of introduction. There is also information on John Vaughan's immigration to America, Joseph Priestley, vaccines and inoculation (with Jefferson's comments on the same), Vaughan's business in Philadelphia, and the American Philosophical Society. Also included in this series are 2 boxes with copies of Vaughan correspondence as well as miscellaneous notes by E. W. Madeira, gathered in the course of his research on Vaughan in the 1930s. Series II consists of three volumes. Included are two of Vaughan's commonplace books. One, entitled, "J. Vaughan's book," May 17, 1779 (47 pp., in Latin; 870/L34), includes mostly Latin notations. The other commonplace book, dated 1783 (ca. 66 pp.; B V 462.c), includes comments on several prominent Americans, such as Benjamin Rush and David Rittenhouse, as well as American society generally. The third volume is a copybook with thirty letters spanning the period 1784 to 1801 (B V462.1). Series III includes material relating to Vaughan's administration of the estate of the Philadelphia merchant Samuel Merrick, 1796-1822 (Vaughan-Merrick Papers, B V462.m; 2 boxes). Series IV consists of correspondence between Vaughan and the DuPont Co. for which he served as agent (B V462.4; photocopies of 73 letters).