After William Temple Franklin returned to Europe in 1792, he left oversight of his financial interests in America in the hands of his intimate friend and fellow land speculator, George Fox. A physician and member of the American Philosophical Society, Fox also took possession of the remainder of Benjamin Franklin's papers, which eventually passed through his son, Charles Pemberton Fox, to the APS. The Franklin-Fox Collection contains 98 items, consisting mostly of letters from William Temple Franklin to George Fox regarding land holdings and finances, and retained copies of Fox's letters to Franklin. The correspondence is fairly relentlessly focused on business matters and rarely contains personal comments, however there are occasional requests for books and two reference to the yellow fever epidemic of 1798 and the death of Benjamin Franklin Bache.

Letters written by Julia Rush, wife of Benjamin Rush, mainly to her husband, with one to Samuel Stockton and one to Mary Rush. Eight letters were written during the 1793 yellow fever epidemic. The letters are not included in Lyman Butterfield's edition of Benjamin Rush's letters, vol. 30 of APS Memoirs (1951).

Jacob Hiltzheimer, farmer and assemblyman, emigrated from Germany to Philadelphia in 1748 and lead a moderately active political and social life. He was a successful farmer and raised select livestock in the city of Philadelphia. He also boarded horses including those of John Penn and George Washington. He served in the Pennsylvania Assembly for 11 consecutive years beginning in 1786. He was an active contributor in civil affairs and took a remarkable enthusiastic interest in events, in persons, and in every day life all of which he wrote down in his diary. As a result of his Revolutionary War and political acquaintances his contacts were numerous. Hiltzheimer's record of social affairs are for the most part routine daily events such as buying and trading horses, attending barbecues and funerals, and drinking punch. However it is his every day accounts that also records significant events such as the Revolutionary War, transactions of the Pennsylvania Assembly, and Philadelphia's yellow fever epidemics, as well as the dealings of significant people including George Washington, Thomas Mifflin, and John Hancock.

Catherine Wistar Bache (1805-1886) was the point of connection between two of Philadelphia's most illustrious families of the late eighteenth century. Daughter of the physician Caspar Wistar, in November 1797 she married Dr. William Bache, who was the son of Richard Bache and the grandson of Benjamin Franklin. Primarily letters to Mrs. Bache (wife of Dr. William Bache) of Philadelphia, from Mrs. David Hosack (nee Mary Eddy), Mrs. Elizabeth Trist, and Mary Jones. The letters are personal and concern family life, activities of husbands, etc., with many references to Caspar Wistar, There are comments on diseases, education (at William and Mary College), war, and politics. References are also made to the deaths of Richard Bache and Caspar Wistar, and to Benjamin Franklin's Stockado (a musical instrument).