An early settler and prominent citizen in the Moravian heartland near Bethlehem, Pennsylvania, Timothy Horsfield was named justice of the peace when Northampton County was formed out of Bucks in 1752, and was one of those given responsibility for the defence of the local white and Christian Indian populations during the French and Indian War. The Horsfield Papers offer a window onto the tumultuous history of northeastern Pennsylvania during the 1750s and 1760s. Comprised largely of correspondence and related documents between Horsfield, William Parsons, and provincial and military authorities, the collection includes important information on the Native tribes' actions (previously described as "Indian assaults") in the region in 1756 and 1757 and the military and diplomatic response of settlers.

James Burd (1726-1793) was well-known in colonial Pennsylvania through his role in the French and Indian War, as well as his connections to many of the colony's leading families (most notably the Shippen family). Initially starting out as a merchant in Philadelphia, Burd became increasingly involved with colonial affairs after moving to Lancaster County with his family in 1752. It would be on the frontier where Burd would make his mark first as a soldier, and later as a magistrate. The Burd-Shippen Papers consist mainly of letters and business documents sent to James Burd, with the bulk of the collection relating to the French and Indian War, 1754-1763, in which Burd served as an officer commanding troops at Fort Augusta and elsewhere. The collection reflects all aspects of Burd's life in Pennsylvania as a merchant, soldier, and magistrate; as well as his involvement with the Shippen family professionally and personally. Intermixed with items sent to Burd are receipts to his wife Sarah Shippen Burd, and correspondence between Edward Shippen and James Hamilton regarding land matters and Indian affairs in Lancaster.

A Sachem and Civil War adjutant to Ulysses Grant, Ely Samuel Parker was an important figure in the Seneca Indian nation during the first half of the nineteenth century. Trained as an engineer, Parker was deeply involved in the Senecas' land disputes with the Ogden Land Company and he played an important role in interpreting Seneca culture for a white audience, most notably as a consultant for Lewis Henry Morgan. Collected by Arthur C. Parker, the Ely Samuel Parker Papers include correspondence, manuscripts, and printed materials relating primarily to Seneca affairs, history, language, and culture, as well as politics, education, engineering, and the Civil War. Among Parker's correspondents were Henry Clay, Millard Fillmore, Henry M. Flagler, Lewis Henry Morgan, Henry Rowe Schoolcraft, Daniel Webster, and Asher Wright. Several letters relate to Parker's service as engineer of public buildings in Galena, Illinois, and to his Masonic activities. Among the noteworthy items in the collection are several essays on Seneca history and culture, a fragment of Parker's diary, 1847, and a significant quantity of material on the Seneca language assembled by Asher Wright.