Principally letters from John Eatton LeConte, John Lawrence LeConte, Joseph LeConte, and Mrs. Jane LeConte Harden to Mrs. Matilda Jane Harden Stevens, Sumner Morrison Ramsey, Mrs. Ann LeConte Stevens, and Louis LeConte pertaining to family matters and natural history.

This collection contains mostly entomological material, with much information on the description and identification of particular insects, entomological collections, and the study of entomology in Europe and the United States. In addition, there are materials on medicine and hospitals during the American Civil War, on the Corps of Topographical Engineers, the United States Army, on natural history in the United States, and on the LeConte's family. Some letters are written to President Rutherford B. Hayes and concern the Commissionership of Agriculture, for which LeConte was considered, but not appointed. Letters of John Eatton LeConte and Joseph LeConte are included.